Results 121 to 130 of about 2,572,208 (344)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The Dark Shadows: Unraveling the Impact of Supervisor Bottom Line Mentality on Workplace Jealousy Through Job Insecurity and Resilience

SAGE Open
Supervisor BLM is referred to as a unidimensional frame of mind that revolves around the attainment of bottom-line outcomes; this mentality is commonly found in today’s organizations.
Sehrish Munaf, Amir Gulzar, Hina Fayyaz
doaj   +1 more source

Diversification of Cultivars and Production of Male Inflorescence Flours for More Sustainable Banana Cultivation

Agriculture
Banana inflorescences are usually discarded, but there has been interest in managing this by-product to turn it into a product with added value.
Lucas Felipe dos Ouros, Magali Leonel, Sarita Leonel, Nicholas Zanette Molha, Paulo Ricardo Rodrigues de Jesus, Hebert Teixeira Cândido, Marco Antonio Tecchio, Mayra Schmidt Rechsteiner, Caio César dos Ouros   +8 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

ELIZABETH SHEEHY, DEFENDING BATTERED WOMEN ON TRIAL: LESSONS FROM THE TRANSCRIPTS (Vancouver, University of British Columbia Press. 2014)

The Windsor Yearbook of Access to Justice, 2015
Katrin Roots
doaj   +1 more source

Variation in Root-Associated Microbial Communities among Three Different Plant Species in Natural Desert Ecosystem

Plants
The process and function that underlie the assembly of root-associated microbiomes may be strongly linked to the survival strategy of plants. However, the assembly and functional changes of root-associated microbial communities in different desert plants
Yulin Zhang, Yi Du, Zhihao Zhang, Waqar Islam, Fanjiang Zeng   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Novel Insights into Botanical Seed Production of Xanthosoma spp. in Cuba

Agronomy
Investigating diverse techniques for promoting flowering in Xanthosoma is crucial for managing sexual reproduction, producing authentic botanical seeds, and increasing Xanthosoma’s genetic diversity.
Alay Jiménez-Medina, Alfredo Morales, Diosdada Galvez-Guerra, Alexander Calero-Hurtado, Kolima Peña-Calzada, Bulent Kukurtcu   +5 more
doaj   +1 more source