Results 101 to 110 of about 1,125,981 (241)

O₂-Generated Electrical and Mechanical Properties of Polyphenol-Mediated Hydrogel Sensor

Gels
The tumor microenvironment contains distinctive biomarkers, including acidic pH, elevated levels of reactive oxygen species (ROS), and hypoxia, necessitating the development of efficient biosensors for simplified cancer detection.
Sunu Hangma Subba, A Hyeon Kim, Anneshwa Dey, Byung Chan Lee, Sung Young Park   +4 more
doaj   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Structural color-based microneedle patch with NIR-triggered on-demand drug release for intelligent treatment of infected wounds

Journal of Nanobiotechnology
Bacterial-infected wounds present a critical clinical challenge due to persistent inflammation, impaired angiogenesis, and the lack of real-time treatment monitoring.
Sijia Huang, Menglan Yang, Chen Ding, Wenfang Du, Shengyuan Yang, Qiang Xi, Fubing Xiao   +6 more
doaj   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Conducting polymer-stabilized nanozymes alleviate sepsis-induced myocardial injury by inhibiting iron accumulation and lipid peroxidation

Nature Communications
Septic cardiomyopathy (SC) is a severe complication of sepsis that significantly increases patient mortality. The onset of SC is associated with excessive reactive oxygen species (ROS), leading to increased oxidative stress and iron accumulation. Herein,
Tingting Wu, Ying Liu, Wei Wang, Rong Sun, Yanyan Wang, Jiangpeng Pan, Jingfei Zhu, Kelong Fan, Qiuran Xu, Wei Jiang   +9 more
doaj   +1 more source

Bifunctionally-regulated ROS dynamics with sub-nanoscale polyoxometalate cluster functionalized Fe3O4 nanozyme for potent infected wound healing

Nano Research
Dynamically modulating the level of reactive oxygen species (ROS) presents a promising strategy for infected wound healing therapy, but conventional approaches predominantly focus on ROS generation, often neglecting the necessity of redox balance.
Zohaib Rana, Yiping Fan, Dongzong Huang, Zahid Hussain, Muhammad Umer Rafique, Wenyu Jia, Yongmei Chen, Xiong Yin, Chang Lu, Amjad Nisar, Rongchen Xu, Hongbo Li, Guolei Xiang   +12 more
doaj   +1 more source

Single–Atom Iron Sites Enable Enhanced Arsenic Removal From Water Through Synergistic Adsorption–Oxidation

Advanced Science, EarlyView.
Single–atom iron anchored on nitrogen–doped porous biochar exhibited ultra–efficient performance, exceptional environmental resilience, and integrated adsorption–oxidation functionality. The multifunctional architecture of the support and the unparalleled reactivity of single–atom iron underpinned the cooperative adsorption and oxidation of As(III ...
Tao Sun, Chao Wang, Shihang Wu, Xiaojia Zhou, Penggang Pei, Huijuan Yu, Yun Zhang, Qingqing Huang, Yuebing Sun   +8 more
wiley   +1 more source

Biomimetic Nanoplatform for Targeted Rheumatoid Arthritis Therapy: Modulating Macrophage Niches Through Self‐Sustaining Positive Feedback‐Driven Drug Release Mechanisms

Advanced Science
The core strategies in treating rheumatoid arthritis (RA) now focus on ameliorating the inflammatory microenvironment and reversing macrophage phenotypes within the joint cavity.
Huichao Xie, Xiaoyu Huang, Bao Li, Yongfeng Chen, Haoran Niu, Tong Yu, Shimei Yang, Shuxin Gao, Yutong Zeng, Tianzhi Yang, Yan Kang, Keda Zhang, Pingtian Ding   +12 more
doaj   +1 more source

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

ROS scavenging Mn₃O₄nanozymes forin vivoanti-inflammation

, 2018
Reactive oxygen species (ROS) scavenging Mn3O4nanozymes effectively protected live mice from ROS-induced ear-inflammationin vivo.
Jiangjiexing Wu, Sheng Zhao, Shichao Lin, Yuan Cheng, Sirong Li, Hui Wei, Jia Yao, Min Zhou, Xiaoyu Wang   +8 more
core   +1 more source