Results 111 to 120 of about 1,125,981 (241)

Enzyme-like biomimetic oral-agent enabling modulating gut microbiota and restoring redox homeostasis to treat inflammatory bowel disease

Bioactive Materials
Reactive oxygen species (ROS), immune dysregulation-induced inflammatory outbreaks and microbial imbalance play critical roles in the development of inflammatory bowel disease (IBD).
Zhangpeng Shi, Xiaohong Li, Jufeng Chen, Zideng Dai, Yefei Zhu, Tan Wu, Qing Liu, Huanlong Qin, Yang Zhang, Hangrong Chen   +9 more
doaj   +1 more source

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Oral delivery of engineered Lactococcus lactis microcapsules expressing antioxidant enzymes for inflammatory bowel disease: Mechanisms of intestinal barrier repair and microbiota modulation

Materials Today Bio
Inflammatory bowel disease (IBD) is characterized by elevated levels of reactive oxygen species (ROS) and pro-inflammatory cytokines, alongside disrupted gut microbiota.
Yue Meng, Chao Miao, Jiaxin Guo, Wei Zhang, Ling Guo, Yu Zhang, Yujun Jiang   +6 more
doaj   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

In situ germination of two tropical recalcitrant seeds and changes in activity of ROS-scavenging enzymes

, 2017
Oxidative metabolism during viability loss in recalcitrant seeds has been previously documented, but little is known about the role of ROS-scavenging enzymes in soil seed bank dynamics, especially in recalcitrant seeds.
Davide, Antonio C., Marques, Elizabeth R., Ailton G. Rodrigues-Junior, Antonio C. Davide, Tatiana A. A. Vaz, Anderson C. José, Rodrigues-Junior, Ailton G., Elizabeth R. Marques, José, Anderson Cleiton, Vaz, Tatiana A. A.   +9 more
core   +1 more source

Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing

Advanced Science, EarlyView.
MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang, Jiaxin Tian, Xiaolong Zhu, Xiao Li, Xiangshu Qiu, Yuanyuan Li, Ben Zhong Tang, Ning Shi   +7 more
wiley   +1 more source

Land capability classification for non-rice crops in soils of the sandy terrain of Tram Kak District, Takeo Province [PDF]

, 2006
The expansion of crop diversification in Cambodia in lowlands and in uplands could be facilitated by a process for the assessment of land capability for non-rice crops.
Vance, W., Bell, R.W., White, P.F., Schoknecht, N., Seng, V., Hin, S.   +5 more
core  

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Electroactive Hydrogel Enabling Feedback‑Responsive Monitoring and Regulation of Inflammation for Chronic Wound Therapy

Aggregate
Chronic wounds remain a major clinical challenge due to persistent inflammation, excessive oxidative stress, and impaired tissue regeneration. Herein, we developed a multifunctional hydrogel dressing (GX/ML) by integrating a reactive oxygen species (ROS)‐
Hua Wei, Hongyu Zhao, Xiaohan Li, Jingcheng Hao   +3 more
doaj   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source