Results 121 to 130 of about 1,825,669 (338)

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

GSTM3 Function and Polymorphism in Cancer: Emerging but Promising

Cancer Management and Research, 2020
Shunda Wang, Jinshou Yang, Lei You, Menghua Dai,* Yupei Zhao* Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China*These ...
Wang S, Yang J, You L, Dai M, Zhao Y
doaj  

Reactive oxygen species generated in chloroplasts contribute to tobacco leaf infection by the necrotrophic fungus Botrytis cinerea [PDF]

, 2017
Reactive oxygen species (ROS) play fundamental roles in plant responses to pathogen infection, including modulation of cell death processes and defense-related gene expression.
Bisaro, Fabiana, Carrillo, Nestor Jose, Krapp, Adriana del Rosario, Maiale, Santiago Javier, Pieckenstain, Fernando Luis, Rossi, Franco Rubén   +5 more
core   +1 more source

Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy

Science Advances, 2020
We designed a cascade nanozyme with both superoxide dismutase– and catalase-mimicking activities for anti-inflammation therapy. Here, an integrated cascade nanozyme with a formulation of Pt@PCN222-Mn is developed to eliminate excessive reactive oxygen ...
Yufeng Liu, Yuan Cheng, He Zhang, Min Zhou, Yijun Yu, Shichao Lin, B. Jiang, Xiaozhi Zhao, L. Miao, Chuanwan Wei, Quanyi Liu, Ying-Wu Lin, Yan Du, Christopher J. Butch, Hui Wei   +14 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

N-Butyrylated hyaluronic acid ameliorates gout and hyperuricemia in animal models

Pharmaceutical Biology, 2019
Context: Hyaluronic acid (HA) plays critical roles in the structural skeleton, joint lubrication, renal function and cell signaling. We previously showed that partially N-butyrylated, low molecular weight, hyaluronic acid (BHA) exhibited an anti ...
Lanzhou Li, Di Wang, Xueju Wang, Ruifeng Bai, Chunyu Wang, Yin Gao, Tassos Anastassiades   +6 more
doaj   +1 more source

Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. [PDF]

, 2012
The altered metabolism of cancer can render cells dependent on the availability of metabolic substrates for viability. Investigating the signaling mechanisms underlying cell death in cells dependent upon glucose for survival, we demonstrate that glucose ...
Graeber, Thomas G, Graham, Nicholas A, Kohli, Bitika, Komisopoulou, Evangelia, Lo, Roger S, Mellinghoff, Ingo K, Mischel, Paul S, Ribas, Antoni, Tahmasian, Martik, Teitell, Michael A, Vivanco, Igor, Wu, Hong, Zhu, Maggie   +12 more
core  

Menadione-induced oxidative stress re-shapes the oxylipin profile of Aspergillus flavus and its lifestyle [PDF]

, 2015
Aspergillus flavus is an efficient producer of mycotoxins, particularly aflatoxin B1, probably the most hepatocarcinogenic naturally-occurring compound.
Cigliano, Riccardo Aiese, Fanelli, Corrado, Ippolito, Antonio, Ludovici, Matteo, Reverberi, Massimo, Sanseverino, Walter, Sanzani, Simona Marianna, Scala, Valeria, Scarpari, Marzia, Zaccaria, Marco   +9 more
core   +2 more sources

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Mechanisms of ROS Regulation of Plant Development and Stress Responses

Frontiers in Plant Science, 2019
Plants are subjected to various environmental stresses throughout their life cycle. Reactive oxygen species (ROS) play important roles in maintaining normal plant growth, and improving their tolerance to stress.
Honglin Huang, F. Ullah, Daoxiu Zhou, Ming Yi, Yu Zhao   +4 more
semanticscholar   +1 more source