Results 41 to 50 of about 29,549 (204)

The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status. [PDF]

, 2017
DNA methylation is associated with gene silencing in eukaryotic organisms. Although pathways controlling the establishment, maintenance and removal of DNA methylation are known, relatively little is understood about how DNA methylation influences gene ...
Chen, Xuemei, Feng, Ying, Gao, Lei, Guo, Hongwei, Kim, Yun Ju, Law, Julie A, Le, Brandon, Li, Dongming, Li, Shaofang, Li, Shengben, Liu, Jinyuan, Liu, Li, Liu, Xigang, Mo, Beixin, Palanca, Ana Marie S, Vashisht, Ajay A, Wohlschlegel, James A, Won, So Youn, Wu, Xiuyun, Yang, Guodong, Zhao, Yuanyuan   +20 more
core   +3 more sources

Immunohistochemical detection of ROS1 is useful for identifying ROS1 rearrangements in lung cancers [PDF]

Modern Pathology, 2014
The recent discovery and characterization of an oncogenic ROS1 gene fusion in a subset of lung cancers has raised significant clinical interest because small molecule inhibitors may be effective to these tumors. As lung cancers with ROS1 rearrangements comprise only 1-3% of lung adenocarcinomas, patients with such tumors must be identified to gain ...
Akihiko, Yoshida, Koji, Tsuta, Susumu, Wakai, Yasuhito, Arai, Hisao, Asamura, Tatsuhiro, Shibata, Koh, Furuta, Takashi, Kohno, Ryoji, Kushima   +8 more
openaire   +2 more sources

Association between PD-L1 expression with EGFR, ALK, and ROS1 driver oncogene mutations in non-small cell lung cancer

Indian Journal of Pathology and Microbiology
Background: Driver mutations and immunological expressions have gained importance in recent years for targeted therapies and immunotherapies of nonsmall cell lung cancer (NSCLC). Aims: This study examined the association between PD-L1 expression and ALK,
Dülger Onur, Yaylım İlhan, Öz Büge
doaj   +1 more source

DEMETER plays a role in DNA demethylation and disease response in somatic tissues of Arabidopsis

Epigenetics, 2019
DNA demethylases function in conjunction with DNA methyltransferases to modulate genomic DNA methylation levels in plants. The Arabidopsis genome contains four DNA demethylase genes, DEMETER (DME), REPRESSOR OF SILENCING 1 (ROS1) also known as DEMETER ...
Ulrike Schumann, Joanne M. Lee, Neil A. Smith, Chengcheng Zhong, Jian-Kang Zhu, Elizabeth S. Dennis, Anthony A. Millar, Ming-Bo Wang   +7 more
doaj   +1 more source

Symptomatic CNS Radiation Necrosis Requiring Neurosurgical Resection During Treatment with Lorlatinib in ALK-Rearranged NSCLC: A Report of Two Cases. [PDF]

, 2020
Central nervous system (CNS) metastasis carries a significant morbidity and mortality in anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC).
Al-Holou, Wajd, Armas, Octavio, Kubota, Takafumi, Nagasaka, Misako, Ou, Sai-Hong Ignatius, Raval, Kunil, Robinette, Natasha, Zhu, Viola W   +7 more
core   +1 more source

On Hirschman and log-Sobolev inequalities in mu-deformed Segal-Bargmann analysis

, 2005
We consider a deformation of Segal-Bargmann space and its transform. We study L^p properties of this transform and obtain entropy-entropy inequalities (Hirschman) and entropy-energy inequalities (log-Sobolev) that generalize the corresponding known ...
Angulo C, Angulo C Sontz S B, Bargmann V, Bennett C, Claudio de Jesús Pita Ruiz Velasco, Folland G B, Gross L, Hall B, Hirschman I I, Jörgens K, Lebedev N N, Lieb E H, Marron C S, Pita C, Pita C, Reed M, Rosenblum M, Rosenblum M, Rösler M, Segal I E, Segal I E, Shannon C, Sobolev S L, Sobolev S L, Sontz S B, Stephen Bruce Sontz, Watson G N, Weiss G   +27 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

De Novo Mutation in Non-Tyrosine Kinase Domain of ROS1 as a Potential Predictor of Immune Checkpoint Inhibitors in Melanoma

Frontiers in Oncology, 2021
PurposeDespite the success of targeted therapy in c-ros oncogene 1 (ROS1)-rearranged cancers, especially non-small cell lung cancer (NSCLC), the clinical significance of ROS1 de novo mutation has not yet been understood.
Si-Cong Ma, Si-Cong Ma, Hong-Bo Zhu, Jian Wang, Yan-Pei Zhang, Yan-Pei Zhang, Xue-Jun Guo, Li-Li Long, Ze-Qin Guo, De-Hua Wu, Zhong-Yi Dong, Xue Bai   +11 more
doaj   +1 more source

The DNA Repair Protein XRCC1 Functions in the Plant DNA Demethylation Pathway by Stimulating Cytosine Methylation (5-meC) Excision, Gap Tailoring, and DNA Ligation [PDF]

, 2013
Background: Active DNA demethylation in plants is initiated by 5-meC DNA glycosylases of the ROS1/DME family and continued through a base excision repair pathway.
Córdoba-Cañero, Dolores, Martínez-Macías, M.I., Rodríguez Ariza, Rafael, Roldán-Arjona, Teresa   +3 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source