Results 21 to 30 of about 110,610 (219)

Reactive oxygen species-scavenging nanomaterials for the prevention and treatment of age-related diseases

Journal of Nanobiotechnology
With increasing proportion of the elderly in the population, age-related diseases (ARD) lead to a considerable healthcare burden to society. Prevention and treatment of ARD can decrease the negative impact of aging and the burden of disease.
Yun Dai, Yifan Guo, Weicheng Tang, Dan Chen, Liru Xue, Ying Chen, Yican Guo, Simin Wei, Meng Wu, Jun Dai, Shixuan Wang   +10 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Phytochemical and computational characterization, ROS scavenging properties of

Sustainable Chemistry for Climate Action
Numerous nanomedicine and materials science applications have piqued interest in environmentally friendly nanoparticle production. In this study, reduced graphene oxide (rGO) nanosheets were prepared using a bio reductant in the edible and medicinally ...
Mansi Yadav, Jaya Parkash Yadav, Sudhir Kumar Kataria   +2 more
doaj   +1 more source

ROS regulation in gliomas: implications for treatment strategies

Frontiers in Immunology, 2023
Gliomas are one of the most common primary malignant tumours of the central nervous system (CNS), of which glioblastomas (GBMs) are the most common and destructive type. The glioma tumour microenvironment (TME) has unique characteristics, such as hypoxia,
Yu-Chen Yang, Yu Zhu, Yu Zhu, Si-Jia Sun, Can-Jun Zhao, Yang Bai, Jin Wang, Jin Wang, Li-Tian Ma, Li-Tian Ma, Li-Tian Ma   +10 more
doaj   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Biomass Native Structure Into Functional Carbon‐Based Catalysts for Fenton‐Like Reactions

Advanced Functional Materials, EarlyView.
This study indicates that eight biomasses with 2D flaky and 1D acicular structures influence surface O types, morphology, defects, N doping, sp2 C, and Co nanoparticles loading in three series of carbon, N‐doped carbon, and cobalt/graphitic carbon. This work identifies how these structural factors impact catalytic pathways, enhancing selective electron
Wenjie Tian, Jingkai Lin, Zhihao Tian, Selusiwe Ncube, Huayang Zhang, Emiliano Cortés, Hongqi Sun, Shaobin Wang   +7 more
wiley   +1 more source

Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells

Antioxidants, 2020
Reactive oxygen species (ROS) constitute a homeostatic rheostat that modulates signal transduction pathways controlling cell turnover. Most oncogenic pathways activated in cancer cells drive a sustained increase in ROS production, and cancer cells are ...
Francesco Ciccarese, Vittoria Raimondi, Evgeniya Sharova, Micol Silic-Benussi, Vincenzo Ciminale   +4 more
doaj   +1 more source

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

A Pseudo‐Two‐Dimensional Reaction–Diffusion Model for Rational Design of Antibacterial–Antioxidant Ag–ZnO/Fucoidan Nanocomposites

Engineering Reports
Reactive oxygen species (ROS)–generating nanocomposites exhibit strong antibacterial activity; however, uncontrolled ROS release often induces oxidative toxicity and limits their practical applicability. Achieving a rational balance between antimicrobial
Mohamed Abu Shuheil, Maryam Saleem Mohammed Ali, Roopashree R., Subhashree Ray, Baraa Mohammed Yaseen, Kavitha V., Renu Sharma, Aashna Sinha, Naser Aslanian   +8 more
doaj   +1 more source

High‐Efficiency Quantum Defect Generation in Carbon Nanotubes via Oxygen‐Free Photochemistry

Advanced Functional Materials, EarlyView.
We show that oxygen plays an important role in quantum defect formation in carbon nanotubes and identify reaction conditions to create a range of different quantum defects for photonics and biosensing. ABSTRACT Single‐walled carbon nanotubes (SWCNTs) offer potential for a wide range of applications from optoelectronic devices to biomedical diagnostics.
Christina Derichsweiler, Valeriia D. Andreeva, Jan Stegemann, Julia Ackermann, Janus A. C. Wartmann, Svenja Herbertz, Sebastian Kruss   +6 more
wiley   +1 more source