Results 31 to 40 of about 593,713 (266)

A Curcumin‐Modified Coordination Polymers with ROS Scavenging and Macrophage Phenotype Regulating Properties for Efficient Ulcerative Colitis Treatment

Advancement of science, 2023
Overexpression of classically activated macrophages (M1) subtypes and assessed reactive oxygen species (ROS) levels are often observed in patients with ulcerative colitis.
Hang Yao, Feifei Wang, Hui Chong, Jingjing Wang, Yang Bai, Meng Du, Xiaohui Yuan, Xiaofei Yang, Ming Wu, Yuping Li, H. Pang   +10 more
semanticscholar   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Phytochemical and computational characterization, ROS scavenging properties of

Sustainable Chemistry for Climate Action
Numerous nanomedicine and materials science applications have piqued interest in environmentally friendly nanoparticle production. In this study, reduced graphene oxide (rGO) nanosheets were prepared using a bio reductant in the edible and medicinally ...
Mansi Yadav, Jaya Parkash Yadav, Sudhir Kumar Kataria   +2 more
doaj   +1 more source

ROS regulation in gliomas: implications for treatment strategies

Frontiers in Immunology, 2023
Gliomas are one of the most common primary malignant tumours of the central nervous system (CNS), of which glioblastomas (GBMs) are the most common and destructive type. The glioma tumour microenvironment (TME) has unique characteristics, such as hypoxia,
Yu-Chen Yang, Yu Zhu, Yu Zhu, Si-Jia Sun, Can-Jun Zhao, Yang Bai, Jin Wang, Jin Wang, Li-Tian Ma, Li-Tian Ma, Li-Tian Ma   +10 more
doaj   +1 more source

Dual-ROS-scavenging and dual-lingering nanozyme-based eye drops alleviate dry eye disease

Journal of Nanobiotechnology
Efficiently removing excess reactive oxygen species (ROS) generated by various factors on the ocular surface is a promising strategy for preventing the development of dry eye disease (DED).
Wei Zhang, Mengyang Zhao, Dandan Chu, Hui-Ying Chen, Bingbing Cui, Qingyun Ning, Xing Wang, Zhan-Rong Li, Shaokui Cao, Jingguo Li   +9 more
semanticscholar   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Mesoporous MOFs with ROS scavenging capacity for the alleviation of inflammation through inhibiting stimulator of interferon genes to promote diabetic wound healing

Journal of Nanobiotechnology
Excessive production of reactive oxygen species (ROS) and inflammation are the key problems that impede diabetic wound healing. In particular, dressings with ROS scavenging capacity play a crucial role in the process of chronic wound healing.
Fu-Peng Li, Zhiyuan Mao, Yun Du, Yuehan Cui, Sheng-Bing Yang, Kai Huang, Jian Yang, Zhuoyuan Li, Yi-Hao Liu, Jin-Lou Gu, Dan-Ru Wang, Chen Wang   +11 more
semanticscholar   +1 more source

Hollow manganese dioxide-chitosan hydrogel for the treatment of atopic dermatitis through inflammation-suppression and ROS scavenging

Journal of Nanobiotechnology, 2023
Atopic dermatitis (AD) is a chronic inflammatory disease associated with immune dysfunction. High levels of reactive oxygen species (ROS) can lead to oxidative stress, release of pro-inflammatory cytokines, and T-cell differentiation, thereby promoting ...
Yaguang Wu, Zihao Zhou, Min Zhang, Song Li, Mengyi Sun, Zhiqiang Song   +5 more
semanticscholar   +1 more source

Biomass Native Structure Into Functional Carbon‐Based Catalysts for Fenton‐Like Reactions

Advanced Functional Materials, EarlyView.
This study indicates that eight biomasses with 2D flaky and 1D acicular structures influence surface O types, morphology, defects, N doping, sp2 C, and Co nanoparticles loading in three series of carbon, N‐doped carbon, and cobalt/graphitic carbon. This work identifies how these structural factors impact catalytic pathways, enhancing selective electron
Wenjie Tian, Jingkai Lin, Zhihao Tian, Selusiwe Ncube, Huayang Zhang, Emiliano Cortés, Hongqi Sun, Shaobin Wang   +7 more
wiley   +1 more source

Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells

Antioxidants, 2020
Reactive oxygen species (ROS) constitute a homeostatic rheostat that modulates signal transduction pathways controlling cell turnover. Most oncogenic pathways activated in cancer cells drive a sustained increase in ROS production, and cancer cells are ...
Francesco Ciccarese, Vittoria Raimondi, Evgeniya Sharova, Micol Silic-Benussi, Vincenzo Ciminale   +4 more
doaj   +1 more source