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Biochemical Engineering Perspective on cGAS: From Enzyme Discovery to Potential Industrial Application

open access: yesChemBioChem, Volume 27, Issue 5, 13 March 2026.
This review examines the structural and enzymatic properties of cyclic GMP‐AMP synthase, including substrate promiscuity, homologs, and engineered variants. In addition, it evaluates potential expression systems for large‐scale enzyme production and analyzes reaction and purification strategies for the synthesis of cyclic dinucleotides to connect ...
Makram Fataeri, Katrin Rosenthal
wiley   +1 more source

Evolutionarily diverse caveolins share a common structural framework built around amphipathic disks. [PDF]

open access: yesJ Cell Biol
Han B   +8 more
europepmc   +1 more source

Biophysics-based protein language models for protein engineering. [PDF]

open access: yesNat Methods
Gelman S   +7 more
europepmc   +1 more source

Structure of a transient protein-folding intermediate by pressure-jump NMR spectroscopy. [PDF]

open access: yesProc Natl Acad Sci U S A
Masoumzadeh E   +5 more
europepmc   +1 more source

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