Results 171 to 180 of about 16,425 (239)
Advanced Science, Volume 13, Issue 51, 14 September 2026.Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu +9 more
wiley +1 more source
Advanced Science, Volume 13, Issue 51, 14 September 2026.Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang +8 more
wiley +1 more source
Rosetta Stone: A Consideration of the Dardenne Brothers' Rosetta
Journal of Religion & Film, 2002 openaire +1 more source
Land Degradation &Development, Volume 37, Issue 15, Page 10993-11008, September 2026.ABSTRACT Afforestation in the desert–oasis ecotone induces soil desiccation and secondary salinization. However, the seasonal dynamics of soil water–heat–salt interactions across plantations of different stand ages in arid regions remain unclear. Here, we investigated the seasonal patterns and coupled relationships of soil water–heat–salt dynamics in ...
Wang Yanxin +3 more
wiley +1 more source
Protein Science, Volume 35, Issue 9, September 2026.Abstract The design of proteins with desired biophysical properties, such as high solubility and low aggregation propensity, is crucial for various biotechnological and biomedical applications. While deep learning‐based methods like ProteinMPNN have shown remarkable success in protein sequence design, their direct output may not always exhibit optimal ...
Sacha T. Larda +2 more
wiley +1 more source
Conformational diversity in poly‐HAMP arrays and its implications for signal transduction
Protein Science, Volume 35, Issue 9, September 2026.Abstract Prokaryotic transmembrane receptors are built around a helical coiled‐coil backbone, with sensory, modulatory, and effector domains arranged along its length. The modulatory HAMP domain forms a parallel four‐helix coiled coil integrated into this backbone, typically connecting transmembrane segments with downstream cytosolic domains.
Murray Coles +8 more
wiley +1 more source
AVIDbase: A biologically accurate structural dataset of nanobody‐antigen complexes
Protein Science, Volume 35, Issue 9, September 2026.Abstract Accurate structural data in a standardized format is one of the key factors behind the success of machine learning (ML)‐based methods for protein design and structure prediction. However, their application to nanobody‐antigen complexes has lower success rates compared to globular protein complexes, partly due to the limited amount of high ...
Tadej Medved +3 more
wiley +1 more source
WIREs Computational Molecular Science, Volume 16, Issue 5, September/October 2026.Protein deep learning is moving from single structure prediction toward bound complex modeling and conformational ensemble generation. An architectural perspective shows how symmetry, evolutionary information, generative sampling, and energetic grounding shape performance and generalization.
Daniele Angioletti +3 more
wiley +1 more source
Reviews of Geophysics, Volume 64, Issue 3, September 2026.Abstract Understanding the coastal zone of the Antarctic Ice Sheet (AIS), where it interacts with the Southern Ocean and warmer air masses, is crucial for predicting Antarctica's influence on the global climate and sea level. This region has multiple tipping mechanisms that could trigger large, rapid, and potentially irreversible changes in the AIS ...
Kenichi Matsuoka +79 more
wiley +1 more source