Results 161 to 170 of about 42,471 (305)

Improving Protein Structure Determination by Integrating Ensemble-Driven Molecular Dynamics with Chemical Shift-Based Restraints. [PDF]

J Chem Inf Model
Gadanecz M, Fazekas Z, Menyhárd DK, Perczel A.   +3 more
europepmc   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Rosetta Statements: simplifying FAIR knowledge graph construction with a user-centred approach. [PDF]

Database (Oxford)
Vogt L, Farfar KE, Karanth P, Konrad M, Oelen A, Prinz M, Strömert P.   +6 more
europepmc   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, Volume 13, Issue 33, 15 June 2026.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Chitosan and its derivatives in Lady Rosetta potatoes:In vivo gene expression modulation driving growth, yield, quality, and antibacterial defense. [PDF]

Sci Rep
Zakaria TY, El-Soda M, ElFoli AF, Hussein MH, Gabr AMM.   +4 more
europepmc   +1 more source

Piedra Rosetta

, 2015
ESP
openaire   +1 more source

BLADE‐ON‐PETIOLE Genes Enable Genetic Bottleneck Mitigation Through Cross‐Species Repurposing of Floral Persistence Traits

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study shows that BLADE‐ON‐PETIOLE (BOP) proteins regulate floral abscission and senescence in tomato by interacting with TFAM1 to form transcriptional condensates controlling the ARABIDOPSIS THALIANA HOMEOBOX GENE 1 (ATH1)‐mediated abscission pathway.
Nan Xiao, Qianwen Lyu, Tinghao Zhang, Yupan Zou, Yue Xie, Dandan Yang, Cao Xu, Xiaozhen Huang   +7 more
wiley   +1 more source

Overcoming extrapolation challenges of deep learning by incorporating physics in protein sequence-function modeling. [PDF]

PLoS Comput Biol
Barethiya S, Huang J, Stumpf C, Liu X, Guan H, Chen J.   +5 more
europepmc   +1 more source

A Modular and Programmable Cas13d Platform for RNA Single Nucleotide Variant Detection

Advanced Science, Volume 13, Issue 32, 9 June 2026.
A scenario‐guided Cas13d platform enables configurable single nucleotide variant ribonucleic acid diagnostics through rule‐based guide design and ribonucleic acid binding domain engineering, supporting amplification‐free ultrasensitive detection and amplification‐coupled robust detection for accurate mutation classification in clinical tumor specimens.
Zeyu Wang, Jiahao Li, Zhuying Yue, Beixuan He, Wenhua Zhang, Zhen Fang, Qing Xia, Yingbin Liu, Yanjing Li   +8 more
wiley   +1 more source

Canada1Water: Hydraulic parametrized integrated soil, bedrock and peatlands datasets. [PDF]

Data Brief
Kessel ED, Frey SK, Lapen DR, Geng X, Russell HAJ.   +4 more
europepmc   +1 more source