Results 161 to 170 of about 16,425 (239)
The Journal of Physiology, EarlyView.Abstract figure legend We tested the hypothesis that cAMP binding to HCN2 channels in nociceptors is a causal driver of neuropathic pain by using TRIP8bnano, a synthetic peptide we previously developed as a selective antagonist of cAMP in HCN channels. TRIP8bnano effectively abolishes cAMP potentiation of HCN2 currents in small‐diameter DRG neurons and
Santiago I. Loya‐Lopez +7 more
wiley +1 more source
Protein Science, Volume 35, Issue 10, October 2026.Abstract Deoxyuridine triphosphatase (dUTPase) is essential for DNA replication fidelity and embryonic development in metazoa, yet whether a protein inhibitor can acutely disrupt dUTPase function in a living vertebrate has not been tested. The Staphylococcus aureus Stl protein inhibits diverse dUTPases in vitro, but its efficacy in a eukaryotic ...
Viktória Perey‐Simon +7 more
wiley +1 more source
Engineering a protein homodimer from a heterodimer: A chimeric DBHS protein
Protein Science, Volume 35, Issue 10, October 2026.Abstract Drosophila behavior/human splicing (DBHS) proteins are involved at nearly every stage of the RNA lifecycle. There are three paralogues in mammals—SFPQ, NONO and PSPC1—which form both homodimer and heterodimers. It is likely that the non‐redundant and overlapping roles of the different DBHS paralogues emerge from their dynamic and combinatorial
Andrew C. Marshall +5 more
wiley +1 more source
Protein Science, Volume 35, Issue 10, October 2026.Abstract Autoantibodies against tumor‐associated autoantigens are clinically valuable biomarkers for cancer diagnosis; however, the structural determinants governing epitope selectivity remain unknown. Here, we investigated whether the intrinsic conformational stability of target autoantigens regulates the epitope propensity of tumor‐associated ...
Ai Miyamoto +13 more
wiley +1 more source
Journal of Field Robotics, Volume 43, Issue 7, Page 4475-4514, October 2026.ABSTRACT As a crucial puzzle piece of deep space exploration, exploring small bodies can provide significant scientific insights and valuable mineral resources. Unlike missions to the Moon and Mars, small‐body missions pose distinct technical challenges, including communication delays, weak gravity, and uncertain environments. This paper reviews a full
Xin Zhang +3 more
wiley +1 more source
The CaM1‐CBP60b‐MYB77 Transcriptional Cascade Regulates K+ Homeostasis and Salt Tolerance in Barley
Plant Biotechnology Journal, Volume 24, Issue 10, Page 5248-5265, October 2026.ABSTRACT Soil salinity is a major abiotic stress that threatens global crop productivity. Calcium (Ca2+) is a pivotal second messenger in plant stress signalling, but how Ca2+ sensors such as calmodulin (CaM) transcriptionally control ion homeostasis and salt tolerance remains largely understood in crops.
Yunfeng Xu +18 more
wiley +1 more source
Plant Biotechnology Journal, Volume 24, Issue 10, Page 5320-5339, October 2026.ABSTRACT Microtubules (MTs) are crucial for cell division, growth, development and morphogenesis in plants. Cotton fibres are single‐celled trichomes that originate from the epidermal cells of the ovule, making them an excellent model for studying plant cell differentiation and rapid elongation.
Xiaowei Ma +18 more
wiley +1 more source
Evaluating the Validity of Model Organisms: A Review and a New Framework for Biologists
The FASEB Journal, Volume 40, Issue 17, 15 September 2026.This article provides an overview on model organisms and proposes a new framework for assessing the extent to which it is justified to generalize the results obtained from a given organism. It covers both studies of human diseases and those focused on general biological processes. The first part of the article is a review on model organisms.
Héloïse Athéa, Nicolas Heck
wiley +1 more source
Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity
Advanced Science, Volume 13, Issue 50, 7 September 2026.Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai +7 more
wiley +1 more source