A hybrid evolutionary and structural method for AI-guided peptide inhibitor design using AlphaFold and Rosetta. [PDF]
Chaves Carvalho F +7 more
europepmc +1 more source
Nanobodies: A Promising Toolkit for Diagnostic Applications
This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu +11 more
wiley +1 more source
Visual Recovery with Cryopreserved Amniotic Membrane After Epi-Off Corneal Cross-Linking in Keratoconus Patients: A Non-Randomized, Controlled, Retrospective Study. [PDF]
Rosetta M, Gupta R.
europepmc +1 more source
Abstract Understanding how temporal patterns of moisture and temperature variability influence biogeochemical responses remains a central challenge in modeling the Earth system. Jensen's inequality provides a mathematical framework for quantifying when nonlinear processes cause the response to average conditions to differ systematically from the ...
Yulissa T. Perez Rojas +1 more
wiley +1 more source
Advancing Heliophysics and Space Weather Modeling Through Open Science
Abstract We present a community‐wide effort to develop a strategy and action plan to advance heliophysics and space weather modeling through open science. While open science has the potential to enhance the quality and pace of scientific discovery, its application to scientific modeling requires more careful consideration regarding open data and open ...
C. Corti +87 more
wiley +1 more source
MAVISp: A modular structure-based framework for protein variant effects. [PDF]
Arnaudi M +32 more
europepmc +1 more source
Crystal structure of Plasmodium vivax macrophage migration inhibitory factor
The production, crystallization and 1.8 Å resolution crystal structure of macrophage migratory inhibitory factor from P. vivax are reported.Plasmodium vivax is a major cause of malaria globally and has recently been transmitted locally in the USA. P. vivax produces homologs of host proteins, including cytokines such as macrophage migration inhibitory ...
Aryana Nair +11 more
wiley +1 more source
Mepolizumab as a Possible Treatment for Eosinophilic Ureteritis. [PDF]
Sheth H +4 more
europepmc +1 more source
Niche Overlap Is Not Enough: Same Overlap, Contrasting Fluctuations
Niche overlap summarizes competitive coupling at equilibrium, but it can fail to predict out‐of‐equilibrium dynamics such as temporal abundance correlations. We show that communities with identical niche overlap can exhibit opposite correlation patterns, and that a yield‐depletion mismatch (depletion dissimilarity minus yield dissimilarity ...
Akiva Goldberg +3 more
wiley +1 more source
pCODE tRNA Expression Plasmids Compensate for Rare Codons in Recombinant Protein Production. [PDF]
Feller M +6 more
europepmc +1 more source

