Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor. [PDF]
PLoS ONE, 2011 IntroductionSevere malaria has been attributed partly to the sequestration of Plasmodium falciparum-infected erythrocytes (IEs) in the microvasculature of vital host organs. Identification of P.
Alfredo Mayor +11 more
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Rheopathologic Consequence of Plasmodium vivax Rosette Formation. [PDF]
PLoS Neglected Tropical Diseases, 2016 Malaria parasites dramatically alter the rheological properties of infected red blood cells. In the case of Plasmodium vivax, the parasite rapidly decreases the shear elastic modulus of the invaded RBC, enabling it to avoid splenic clearance.
Rou Zhang +10 more
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Clinical and molecular aspects of severe malaria
Anais da Academia Brasileira de Ciências, 2005 The erythrocytic cycle of Plasmodium falciparum presents a particularity in relation to other Plasmodium species that infect man. Mature trophozoites and schizonts are sequestered from the peripheral circulation due to adhesion of infected erythrocytes ...
Karin Kirchgatter +1 more
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Transcriptomics of Plasmodium vivax rosetting [PDF]
Mem Inst Oswaldo CruzBACKGROUND Plasmodium vivax rosetting is a cytoadhesion phenomenon associated with parasite virulence and clinical manifestations of malaria. However, the molecular mechanisms underlying this process remain poorly understood. Comparative transcriptomic analysis between isolates with different rosetting capacities may provide insights into the molecular
Bourgard C +6 more
europepmc +3 more sources
"Plasmodium falciparum var" Gene Expression Dynamics and its Relevance in Malaria Disease in Children from Papua New Guinea [PDF]
, 2005 Malaria is a tremendous global public health problem. While especially hitting the poorest countries in the world, malaria elicits each year 300 million febrile illnesses and up to 1 million deaths. Widespread drug resistances, climatic changes, but also
Kästli, Mirjam Elisabeth
core +1 more source
Enhanced virulence of Plasmodium falciparum in blood of diabetic patients.
PLoS ONE, 2021 Rising prevalence of diabetes in sub-Saharan Africa, coupled with continued malaria transmission, has resulted more patients dealing with both communicable and non-communicable diseases. We previously reported that travelers with type 2 diabetes mellitus
Jun-Hong Ch'ng +7 more
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High levels of Plasmodium falciparum rosetting in all clinical forms of severe malaria in African children [PDF]
, 2009 Plasmodium falciparum rosetting (the spontaneous binding of infected erythrocytes to uninfected erythrocytes) is a well-recognized parasite virulence factor.
Thera, Mahamadou A +7 more
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Plasmodium falciparum:Rosettes do not protect merozoites from invasion-inhibitory antibodies
, 2006 Rosetting is a parasite adhesion phenotype associated with severe malaria in African children. Why parasites form rosettes is unknown, although enhanced invasion or immune evasion have been suggested as possible functions.
Rowe, J Alexandra; id_orcid +1 more
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Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1. [PDF]
PLoS ONE, 2015 The ABO blood group antigens are expressed on erythrocytes but also on endothelial cells, platelets and serum proteins. Notably, the ABO blood group of a malaria patient determines the development of the disease given that blood group O reduces the ...
Kirsten Moll +4 more
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In vitro inhibition of Plasmodium falciparum rosette formation by Curdlan sulfate
, 2007 Spontaneous binding of infected erythrocytes to uninfected erythrocytes to form rosettes is a property of some strains of Plasmodium falciparum that is linked to severe complications of malaria.
Steen, Katie E +16 more
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