Results 91 to 100 of about 22,842 (183)

An ANGPTL8‐AKT2‐mTOR Axis Drives Adipose Senescence and Aging‐Related Functional Decline

Aging Cell, Volume 25, Issue 8, August 2026.
ANGPTL8 increases with age in humans and mice and serves as a key predictor of biological aging and mortality. Adipocyte‐derived ANGPTL8 promotes cellular senescence through AKT2–mTOR signaling, whereas genetic deletion of Angptl8 attenuates adipose tissue aging and extends lifespan.
Yi He, Limeng Pan, WenJun Ping, Chen Meng, Xiaoyu Meng, Yaming Guo, Ranran Kan, Yuxi Xiang, Beibei Mao, Siyi Wang, Danpei Li, Xuefeng Yu   +11 more
wiley   +1 more source

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

The FEBS Journal, Volume 293, Issue 15, Page 4489-4507, August 2026.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira   +12 more
wiley   +1 more source

The emerging role of the Hippo signaling pathway in interorgan crosstalk

The FEBS Journal, Volume 293, Issue 16, Page 4769-4788, August 2026.
Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song, Chaerin Lee, Eek‐hoon Jho   +2 more
wiley   +1 more source

Rosiglitazone [PDF]

, 2020
openaire   +3 more sources

Primary cardiovascular preventive effect of thiazolidinedione in adults with type 2 diabetes: A nationwide cohort study in Korea

Journal of Diabetes Investigation, Volume 17, Issue 8, Page 1367-1378, August 2026.
Among Korean adults with type 2 diabetes and no prior cardiovascular disease, thiazolidinedione use was associated with a lower risk of the primary composite outcome of stroke, myocardial infarction, hospitalization for heart failure, and all‐cause mortality compared to dipeptidyl peptidase‐4 inhibitor use. ABSTRACT Background Thiazolidinediones (TZDs)
Yun Young Choi, Jimin Jeon, Minyoul Baik, Joonsang Yoo, Jinkwon Kim   +4 more
wiley   +1 more source

RETRACTION: "Influence of Rosiglitazone on the Expression of PPAR<i>γ</i>, NF-<i>κ</i>B,and TNF-<i>α</i> in Rat Model of Ulcerative Colitis". [PDF]

Gastroenterol Res Pract
Research And Practice G.
europepmc   +1 more source

Combined All-trans Retinoic Acid and Rosiglitazone Alleviates Scleroderma Fibrosis by Suppressing the STAT3/Th17 Axis. [PDF]

In Vivo
Shao HM, Chen JJ, Cao SL.
europepmc   +1 more source

Therapeutic potential of low-dose rosiglitazone in periodontitis: attenuation of inflammation and bone loss through macrophage reprogramming. [PDF]

BMC Oral Health
Zhou LN, Zhang Z, Wang ZT.
europepmc   +1 more source

Comparative thromboembolic risk and polypharmacy-related drug-drug interaction signals among antidiabetic medications: a large-scale FAERS pharmacovigilance study. [PDF]

Front Pharmacol
Bafail D, Ghazal H.
europepmc   +1 more source

Topical delivery of a PPARγ agonist enables adipogenic repair of irradiated skin. [PDF]

Mol Ther Adv
Siegel A, Hanumantharao S, Koirala P, Sehgal V, He C, Wu M, Ali Akbari Ghavimi S, Chen Z, Williams Z, Xu X, Liu C, Kozono D, Agarwal S.   +12 more
europepmc   +1 more source