Results 81 to 90 of about 27,657 (222)
ROSIGLITAZONE AND CARDIOVASCULAR RISK – A REVIEW
, 2011 The thiazolidinediones (TZDs) are a class of oral drugs used for the management of type 2 diabetes mellitus and act as ligands for the transcription factor Peroxisome Proliferator-Activated Receptor gamma (PPARγ).
Suleiman Isa, Isa, S
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Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Post‐translational modifications (PTMs) play a critical role in regulating the transcriptional activity of PPARγ, a nuclear receptor central to glucose and lipid homeostasis. Among these, lysine acetylation at K268 and K293 and phosphorylation at S273 are particularly relevant to insulin sensitivity.
Caique Camargo Malospirito +6 more
wiley +1 more source
Rosiglitazone and Fenofibrate Additive Effects on Lipids
, 2011 Background. To evaluate the effect of rosiglitazone, fenofibrate, or their combined use on plasma lipids in normoglycemic healthy adults. Methods and Results.
Dorette Pearce Moore +5 more
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Rosiglitazone: to be or not to be? [PDF]
Diabetologia, 2009 To the Editor: The American Diabetes Association (ADA) and the EASD recently recommended an update [1] to their algorithm for the initiation and adjustment of therapy for the management of hyperglycaemia in type 2 diabetes, which was originally published in 2006 [2] and specifically revised in early 2008 regarding the use of thiazolidinediones [3]. The
openaire +2 more sources
Sexual Safety Signals of Common Antidiabetic Drugs: Insights From FAERS Disproportionality Analysis
Andrology, EarlyView.ABSTRACT Background Erectile dysfunction is a prevalent and distressing complication of diabetes mellitus that markedly affects quality of life in male patients. Although the role of diabetes in erectile dysfunction is well‐established, potential drug‐induced sexual dysfunction associated with commonly prescribed antidiabetic medications remains ...
Shan Lin +3 more
wiley +1 more source
Pioglitazone is a valid alternative to rosiglitazone
, 2011 In 2000, two new thiazolidinediones, pioglitazone and rosiglitazone, were approved for the treatment of type 2 diabetes mellitus (T2DM). Administered as monotherapy or in combination with other antihyperglycemic agents, they represented an effective ...
Giuseppe Derosa, DEROSA, GIUSEPPE
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Rosiglitazone relieves acute ethanol-induced hangover in Sprague-Dawley rats [PDF]
, 2006 Aims: To assess the efficacy of rosiglitazone in blocking ethanol-induced hangover in rats. Methods: Rats injected with ethanol (4 g/kg body weight) were subjected to social interaction tests.
차봉수 +3 more
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PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes
British Journal of Pharmacology, EarlyView.Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier +9 more
wiley +1 more source
Journal of Cardiovascular Magnetic Resonance, 2009 Background There is recent evidence suggesting that rosiglitazone increases death from cardiovascular causes. We investigated the direct effect of this drug on atheroma using 3D carotid cardiovascular magnetic resonance.
Chan Cheuk F +6 more
doaj +1 more source
Science Progress, 2020 Colorectal cancer is one of the most prevalent noncommunicable diseases worldwide. 5-Fluorouracil is the mainstay of chemotherapy for colorectal cancer.
Meng-Fei Lau +3 more
doaj +1 more source