Results 61 to 70 of about 27,657 (222)

Treatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary adenoma and liver

iScience, 2021
Summary: Rosiglitazone, a synthetic peroxisome proliferator-activated receptor γ (PPARγ) ligand, has been reported to reduce growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in 10 patients with acromegaly.
Yichao Zhang, Meng Wang, Chenxing Ji, Zhengyuan Chen, Hui Yang, Lei Wang, Yifei Yu, Nidan Qiao, Zengyi Ma, Zhao Ye, Xiaoqing Shao, Wenjuan Liu, Yi Wang, Wei Gong, Vladimir Melnikov, Lydia Hu, Eun Jig Lee, Hongying Ye, Yongfei Wang, Yiming Li, Min He, Yao Zhao, Zhaoyun Zhang   +22 more
doaj   +1 more source

Effects of rosiglitazone and linoleic acid on human preadipocyte differentiation

, 2003
Background Peroxisome proliferator activated receptor gamma (PPARgamma) is a ligand-activated transcription factor known to be central to both adipose tissue development and insulin action.
Suchting, Steven, Herington, Adrian, Cameron, Donald, Newell, F. M., Newell, Fiona, Joyner, Julie, Joyner, J. M., Suchting, S. J., Hutley, L, Prins, Johannes, Hutley, L. J., Cameron, D. P., Prins, J. B., Herington, A. C.   +13 more
core   +1 more source

Effects of rosiglitazone on serum paraoxonase activity and metabolic parameters in patients with type 2 diabetes mellitus

Brazilian Journal of Medical and Biological Research, 2013
Human serum paraoxonase contributes to the anti-atherogenic effect of high-density lipoprotein cholesterol (HDL-C) and has been shown to protect both low-density lipoprotein cholesterol (LDL-C) and HDL-C against lipid peroxidation.
Y. Atamer, A. Atamer, A.S. Can, A. Hekimoglu, N. Ilhan, N. Yenice, Y. Kocyigit   +6 more
doaj   +3 more sources

MicroRNA‐Seq Analysis Reveals a Critical Role for miR‐222 in Bovine Intramuscular Adipogenesis via the DDIT4/mTORC1 Axis

Animal Research and One Health, EarlyView.
Schematic diagram illustrating how miR‐222 promotes bovine intramuscular adipogenesis by targeting DDIT4 to activate the mTORC1 signaling pathway. ABSTRACT Intramuscular fat (IMF) is a key determinant of beef quality, particularly with respect to tenderness, flavor, and juiciness.
Jianbing Tan, Liang Qiu, Zhenghai Zhou, Zhipeng Zhang, Nanfei Wang, Jiangang Hao, Linsen Zan, Wucai Yang   +7 more
wiley   +1 more source

Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury

Neural Regeneration Research, 2016
Methylprednisolone exhibits anti-inflammatory antioxidant properties, and rosiglitazone acts as an anti-inflammatory and antioxidant by activating peroxisome proliferator-activated receptor-γ in the spinal cord.
Xi-gong Li, Xiang-jin Lin, Jun-hua Du, San-zhong Xu, Xian-feng Lou, Zhong Chen   +5 more
doaj   +1 more source

Trends in the utilization, expenditure and costs of noninsulin glucose‐lowering drugs in the Medicaid population: Steady increases in glucagon‐like peptide‐1 receptor agonist and sodium–glucose transporter‐2 inhibitor use, prices and expenditure

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse changes in the utilization, expenditure and average cost of noninsulin glucose‐lowering drugs (GLDs) between 2008 and 2023. Methods This was a retrospective observational study of 2008–2023 data from the National Medicaid State Drug Utilization database.
Rawan O. Almadfaa
wiley   +1 more source

Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: In vivo and ex vivo studies

Reproductive Biology and Endocrinology, 2010
Background The present study was designed to examine the effect of chronic treatment with rosiglitazone - thiazolidinedione used in the treatment of type 2 diabetes mellitus for its insulin sensitizing effects - on the Leydig cell steroidogenic capacity ...
Lima Maria C, Galdino Suely L, Vieira Juliany, Peixoto Christina A, Udrisar Daniel P, Barros Cleiton D, Saraiva Karina LA, Couto Janaína A, Pitta Ivan R, Wanderley Maria I   +9 more
doaj   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

The autophagic regulation of rosiglitazone-promoted adipocyte browning

Frontiers in Pharmacology
Objective: Browning of white adipocytes is considered an efficient approach to combat obesity. Rosiglitazone induces the thermogenetic program of white adipocytes, but the underlying mechanisms remain elusive.Methods: Expression levels of browning and ...
Yue Li, Wanqing Zheng, Xinhang Li, Zhengwei Lue, Yun Liu, Jiaying Wu, Xiangnan Zhang, Xiangnan Zhang   +7 more
doaj   +1 more source

Effects of 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) and rosiglitazone on human gammadelta2 T cells.

PLoS ONE, 2009
BackgroundThiazolidinediones (TZD) class of drugs, and 15-deoxy-D12,14-prostaglandin J2 (15d-PGJ2) are immune regulators predicted to modulate human autoimmune disease. Their effects on gammadelta T cells, which are involved in animal model and human and
Haishan Li, C David Pauza
doaj   +1 more source