Results 41 to 50 of about 22,842 (183)

Effects of rosiglitazone on serum paraoxonase activity and metabolic parameters in patients with type 2 diabetes mellitus

Brazilian Journal of Medical and Biological Research, 2013
Human serum paraoxonase contributes to the anti-atherogenic effect of high-density lipoprotein cholesterol (HDL-C) and has been shown to protect both low-density lipoprotein cholesterol (LDL-C) and HDL-C against lipid peroxidation.
Y. Atamer, A. Atamer, A.S. Can, A. Hekimoglu, N. Ilhan, N. Yenice, Y. Kocyigit   +6 more
doaj   +3 more sources

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Rosiglitazone and Pioglitazone Alter Aromatase Kinetic Properties in Human Granulosa Cells

PPAR Research, 2011
We have previously reported that, in human granulosa cells, thiazolidinediones rosiglitazone and pioglitazone inhibit estrogen synthesis by interfering with androgen binding to aromatase, without an effect on aromatase mRNA or protein expression.
Takako Araki, Miroslava Varadinova, Michael Goldman, Zev Rosenwaks, Leonid Poretsky, Donna Seto-Young   +5 more
doaj   +1 more source

Treatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary adenoma and liver

iScience, 2021
Summary: Rosiglitazone, a synthetic peroxisome proliferator-activated receptor γ (PPARγ) ligand, has been reported to reduce growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in 10 patients with acromegaly.
Yichao Zhang, Meng Wang, Chenxing Ji, Zhengyuan Chen, Hui Yang, Lei Wang, Yifei Yu, Nidan Qiao, Zengyi Ma, Zhao Ye, Xiaoqing Shao, Wenjuan Liu, Yi Wang, Wei Gong, Vladimir Melnikov, Lydia Hu, Eun Jig Lee, Hongying Ye, Yongfei Wang, Yiming Li, Min He, Yao Zhao, Zhaoyun Zhang   +22 more
doaj   +1 more source

Caveolin‐1 enriched apoptotic bodies derived from oral hard palate orchestrate bone remodeling to treat heterotopic ossification

BMEMat, EarlyView.
Downregulated CAV1 in HO is restored via apoptotic bodies from PMSCs, which reprogram bone remodeling by delivering CAV1 to target cells, highlighting the therapeutic role of EV subtypes in heterotopic ossification. Abstract Heterotopic ossification (HO) is a pathological process characterized by ectopic bone formation in non‐osseous tissues, with an ...
Yuchen Wang, Like Tang, Zhou Yu, Wenjin Cai, Qifeng Jiang, Zhikang Wang, Yitong Chen, Kaichen Lai, Ying Wang, Tim Forouzanfar, Chiyuan Ma, Gang Wu, Tingben Huang, Guoli Yang   +13 more
wiley   +1 more source

Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury

Neural Regeneration Research, 2016
Methylprednisolone exhibits anti-inflammatory antioxidant properties, and rosiglitazone acts as an anti-inflammatory and antioxidant by activating peroxisome proliferator-activated receptor-γ in the spinal cord.
Xi-gong Li, Xiang-jin Lin, Jun-hua Du, San-zhong Xu, Xian-feng Lou, Zhong Chen   +5 more
doaj   +1 more source

A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation

Food Chemistry International, EarlyView.
Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee, Tien‐Fen Kuo, Chun‐Yen Yang, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

Effects of 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) and rosiglitazone on human gammadelta2 T cells.

PLoS ONE, 2009
BackgroundThiazolidinediones (TZD) class of drugs, and 15-deoxy-D12,14-prostaglandin J2 (15d-PGJ2) are immune regulators predicted to modulate human autoimmune disease. Their effects on gammadelta T cells, which are involved in animal model and human and
Haishan Li, C David Pauza
doaj   +1 more source

Risk of death and cardiovascular outcomes with thiazolidinediones: a study with the general practice research database and secondary care data. [PDF]

PLoS ONE, 2011
To describe the likely extent of confounding in evaluating the risks of cardiovascular (CV) events and mortality in patients using diabetes medication.The General Practice Research Database was used to identify inception cohorts of insulin and different ...
Arlene M Gallagher, Liam Smeeth, Suzie Seabroke, Hubert G M Leufkens, Tjeerd P van Staa   +4 more
doaj   +1 more source

Bacterial indole‐3‐butyric acid promotes fish PUFA synthesis

iMetaOmics, EarlyView.
Polyunsaturated fatty acids (PUFAs) are essential nutrients in aquatic products, yet the contribution of gut microbiota‐derived metabolites to PUFA biosynthesis remains largely unknown. In this study, a gut‐derived Bacillus strain was identified to enhance PUFA accumulation via indole‐3‐butyric acid (IBA) production.
Ruojing Li, Biao Yuan, Xin Yi, Jieyan Lin, Bi Huang, Ermei Yin, Jiayu Zhou, Qianwen Min, Meiqi Lv, Bo Zhang, Na Zhao   +10 more
wiley   +1 more source