Results 51 to 60 of about 27,657 (222)

Rosiglitazone Restores Endothelial Dysfunction in a Rat Model of Metabolic Syndrome through PPARγ- and PPARδ-Dependent Phosphorylation of Akt and eNOS

PPAR Research, 2011
Vascular endothelial dysfunction has been demonstrated in metabolic syndrome (MS). Chronic administration of rosiglitazone ameliorates endothelial dysfunction through PPARγ-mediated metabolic improvements.
Zhigang Zhao, Zhidan Luo, Peijian Wang, Jing Sun, Hao Yu, Tingbing Cao, Yinxing Ni, Jing Chen, Zhencheng Yan, Daoyan Liu, Zhiming Zhu   +10 more
doaj   +1 more source

Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies [PDF]

, 2009
Introduction Chronic low-grade inflammation is a significant factor in the development of obesity associated diabetes. This is supported by recent studies suggesting endotoxin, derived from gut flora, may be key to the development of inflammation by ...
Al-Attas, Omar S, Kumar Sudhesh, Shaun L Sabico, da Silva, Nancy F., Sabico, Shaun, McTernan Philip G, Sudhesh Kumar, Omar S Al-Attas, Al-Attas, Omar S., Harte, A. L. (Alison L.), Philip G McTernan, Al-Daghri, Nasser M., Al-Attas Omar S, Al-Rubeaan, Khalid, Alison L Harte, Khalid Al-Rubeaan, Nancy F da Silva, Sabico Shaun L, Kumar, Sudhesh, Al-Rubeaan Khalid, Nasser M Al-Daghri, da Silva Nancy F, Harte Alison L, Al-Daghri Nasser M, McTernan, P. G. (Philip G.)   +24 more
core   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Effects of Rosiglitazone on Flap Viability in Diabetic and Non-Diabetic Rats

, 2012
Aim:Rosiglitazone, a peroksisome proliferator activated receptor-γ agonist, is an oral antidiabetic agent that decreases inflammation, free oxygen radical generation and lipid peroxidation.
Burak Kaya, Hakan Ergün, Aylin Okçu Heper, Mert Demirel, Serdar Mehmet Gültan, Murat Emiroğlu   +5 more
core   +1 more source

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

Rosiglitazone and glimeperide: review of clinical results supporting a fixed dose combination

, 2007
Andreas Pfützner1,2, Birgit Wilhelm1, Thomas Forst1,31IKFE – Institute for Clinical Research and Development, Mainz, Germany; 2University of Applied Sciences, Rheinbach Germany; 3University Hospital, Department of Endocrinology, Mainz ...
Forst, Thomas, Andreas Pfützner, Andreas Pfützner, Pfützner, Andreas, Thomas Forst, Birgit Wilhelm, Wilhelm, Birgit   +6 more
core   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts

, 2010
Objective - The transcription factor peroxisome proliferator-activated receptor (PPAR)-γ plays an important role in controlling cell differentiation. The aim of the present study was to examine whether PPAR-γ expression was reduced in skin scleroderma ...
Stratton, R.J., Denton, C.P., Eastwood, M., Leask, A., Abraham, D.J., Shi-Wen, X.   +5 more
core   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

Effects of rosiglitazone on contralateral iliac artery after vascular injury in hypercholesterolemic rabbits

Thrombosis Journal, 2008
Background The objective was to evaluate the effects of rosiglitazone on iliac arteries of hypercholesterolemic rabbits undergoing balloon catheter injury in the contralateral iliac arteries.
Baroncini Liz, de Noronha Lucia, da Silva Ruy, Prim Camila, Alessi Alexandre, Precoma Dalton, França Neto Olímpio   +6 more
doaj   +1 more source