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Synthesis of rosmarinic acid analogues in Escherichia coli
Biotechnology Letters, 2015To produce rosmarinic acid analogues in the recombinant Escherichia coli BLRA1, harboring a 4-coumarate: CoA ligase from Arabidopsis thaliana (At4CL) and a rosmarinic acid synthase from Coleus blumei (CbRAS).Incubation of the recombinant E. coli strain BLRA1 with exogenously supplied phenyllactic acid (PL) and analogues as acceptor substrates, and ...
Yibin, Zhuang +5 more
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Rosmarinic acid production in Coleus cell cultures
Planta, 1977Cell suspension cultures of Coleus blumei Benth. have been found to accumulate 8-11% of their dry weight as rosmarinic acid (α-O-caffeoyl-3,4-dihydroxyphenyl-lactic acid). Actively-growing tissue converts >20% of exogenously supplied phenylalanine and tyrosine to the caffeoyl ester and this high rate of synthesis coincides with an increase in ...
A, Razzaque, B E, Ellis
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New trends in biotechnological production of rosmarinic acid
Biotechnology Letters, 2014Rosmarinic acid (RA), an ester of caffeic acid and 3,4-dihydroxyphenyl lactic acid, is widely distributed in the plant kingdom. Interest in it is growing due to its promising biological activities, including cognitive-enhancing effects and slowing the development of Alzheimer's disease, cancer chemoprotection or anti-inflammatory activity, among others.
Khojasteh A +4 more
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Rosmarinic Acid and Related Metabolites
2017Rosmarinic acid, an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid, is a specialized plant metabolite that occurs in rather high quantities mainly in species of the subfamily Nepetoideae of the Lamiaceae and the Boraginaceae, but also occurs in separate taxa throughout the plant kingdom.
Soheil Pezeshki, Maike Petersen
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Rosmarinic acid and its derivatives: biotechnology and applications
Critical Reviews in Biotechnology, 2011Rosmarinic acid (RA) is one of the first secondary metabolites produced in plant cell cultures in extremely high yields, up to 19% of the cell dry weight. More complex derivatives of RA, such as rabdosiin and lithospermic acid B, later were also obtained in cell cultures at high yields.
Victor P, Bulgakov +2 more
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Effect of rosmarinic acid and carnosic acid on AGEs formation in vitro
Food Chemistry, 2017This work aimed to investigate the effect of the two main components of rosemary extracts, namely rosmarinic acid (RA) and carnosic acid (CA), on the formation of advanced glycation end-products (AGEs) in vitro. In the bovine serum albumin (BSA)/glucose model, addition of RA and CA at 400μg/mL inhibited fluorescent AGEs by more than 90%, and ...
Wang, M, Ou, S, OU, J, Huang, J
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Phytochemistry Reviews, 2013
Rosmarinic acid (RA) is an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid which is one of the most frequently occurring caffeic acid esters in the plant kingdom besides chlorogenic acid. RA has numerous biological and pharmacological activities. Its occurrence is spread all over the land plant kingdom.
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Rosmarinic acid (RA) is an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid which is one of the most frequently occurring caffeic acid esters in the plant kingdom besides chlorogenic acid. RA has numerous biological and pharmacological activities. Its occurrence is spread all over the land plant kingdom.
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Acta Physiologiae Plantarum, 2012
Medicinal Salvia miltiorrhiza is renowned for its curative effects on cardiovascular diseases. Its biologically active ingredients include rosmarinic acid (RA) and its derivative, salvianolic acid B (SAB). We used available bioinformatics tools to improve our knowledge about the biosynthesis of these phenolic compounds. Our comprehensive description of
Jie Song, Yanyun Ji, Kun Xu, Zhezhi Wang
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Medicinal Salvia miltiorrhiza is renowned for its curative effects on cardiovascular diseases. Its biologically active ingredients include rosmarinic acid (RA) and its derivative, salvianolic acid B (SAB). We used available bioinformatics tools to improve our knowledge about the biosynthesis of these phenolic compounds. Our comprehensive description of
Jie Song, Yanyun Ji, Kun Xu, Zhezhi Wang
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Microbial Synthesis of Six Rosmarinic Acid Derivatives
ChemBioChemRosmarinic acid (RA) is a phytochemical that exhibits a variety of biological activities. The biological synthesis pathway of RA has been well‐established in plants. In this study, the shikimate pathway is engineered to enhance the availability of precursor substrates and the biosynthetic pathway is reconstructed to produce six RA derivatives: p ...
Seung Hoon An +3 more
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