Netrin-5 is highly expressed in neurogenic regions of the adult brain.
Mammalian netrin family proteins are involved in targeting of axons, neuronal migration, and angiogenesis and act as repulsive and attractive guidance molecules. Netrin-5 is a new member of the netrin family with homology to the C345C domain of netrin-1.
Satoru eYamagishi +7 more
doaj +1 more source
Review Article on adult neurogenesis in humans
The concept of neurogenesis in the adult human brain was conceived in the 1960s, revisited in the 1980s and confirmed in the 1990s. It was a controversial area of research due to methodological challenges.
Daba Abdissa, Nigusse Hamba, Asfaw Gerbi
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SURF is a robust reference‐free deconvolution tool that integrates high‐dimensional spatial transcriptomics gene expression analysis with self‐supervised deep learning, enabling effective modeling of non‐linear gene interactions and spot relationships.
Shuyu Liang +9 more
wiley +1 more source
Adult Striatal Neurogenesis—A Comparative Approach Between Pigeons, Mice, Macaques, and Human
Striatal adult neurogenesis is an understudied field. Here, we add new quantitative data showing that pigeons provide high levels of adult neurogenesis in the striatum compared to mice. Besides, we show that macaque and human differ in their potential to produce adult‐born neurons at least in the caudate nucleus.
Christina Herold +5 more
wiley +1 more source
Reelin Signaling by the Prime Neurogenic Niche of the Adult Brain
Background: During development, reelin sets the pace of neocortical neurogenesis, enabling newborn neurons to migrate. However, whether—and, if so, how—reelin signaling affects the adult neurogenic niches remains uncertain. Methods: In the present study,
Francisco Javier Pérez-Martínez +2 more
doaj +1 more source
Rhombomere of origin determines autonomous versus environmentally regulated expression of Hoxa3 in the avian embryo [PDF]
We have investigated the pattern and regulation of Hoxa3 expression in the hindbrain and associated neural crest cells in the chick embryo, using whole mount in situ hybridization in conjunction with DiI labeling of neural crest cells and microsurgical ...
Ariza-McNaughton, Linda +4 more
core
Magnetic resonance imaging of migrating neuronal precursors in normal and hypoxic-ischemic neonatal rat brains by intraventricular MPIO labeling [PDF]
Proceedings of the IEEE Engineering in Medicine and Biology Society Conference, 2008, p. 363-366In this study, 10-day-old normal rats (n=6) and hypoxic-ischemic (H-I) neonatal rats (n=6) were injected with the micronsized iron oxide particles (MPIOs ...
Liu, J, Liu, Y, Niu, G, Wu, EX, Yang, J
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Cell migration into the damaged brain mediated by increased cell adhesion
A new paper published in EMBO Molecular Medicine, Matsumoto et al (2024), elegantly shows that polysialic acid (PSA), has a new function—inhibition of migration. Molecular control over cell migration during brain development is essential for proper brain
Jemima Becker, Francis Szele
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Mouse Subependymal Zone Explants Cultured on Primary Astrocytes
Neuroblast migration is a major component in the process of neuronal circuit assembly. In the rodent postnatal brain, the subependymal zone (SEZ) is the largest neurogenic niche where new neurons are born throughout life.
Ionut Dumitru +2 more
doaj +1 more source
Persistent Inflammation Alters the Function of the Endogenous Brain Stem Cell Compartment [PDF]
Endogenous neural stem/precursor cells (NPCs) are considered a functional reservoir for promoting tissue homeostasis and repair after injury, therefore regenerative strategies that mobilize these cells have recently been proposed.
Alfaro-Cervello, Clara +13 more
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