Results 121 to 130 of about 58,009 (170)

Purinergic actions on neurons that modulate nociception in the rostral ventromedial medulla

Neuroscience, 2007
The rostral ventromedial medulla (RVM) serves as a critical link in bulbo-spinal nociceptive modulation. Within the RVM, 'off-cells' pause and 'on-cells' discharge immediately prior to a nocifensive reflex. These neurons are also activated and inactivated, respectively, by local or systemic application of opioids.
N R, Selden, J D, Carlson, J, Cetas, L N, Close, M M, Heinricher   +4 more
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Neural Basis for the Hyperalgesic Action of Cholecystokinin in the Rostral Ventromedial Medulla

Journal of Neurophysiology, 2004
The analgesic actions of opioids can be modified by endogenous “anti-opioid” peptides, among them cholecystokinin (CCK). CCK is now thought to have a broader, pronociceptive role, and contributes to hyperalgesia in inflammatory and neuropathic pain states.
Mary M, Heinricher, Miranda J, Neubert
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Internal connections in the rostral ventromedial medulla of the rat

Journal of the Autonomic Nervous System, 1995
Physiological and pharmacological data suggest that the rostral ventromedial medulla (RVM) is an important site where integration between somatic and visceral functions might occur. The aim of the present study was to describe the interconnections between various nuclei of the rostral ventromedial medulla and thus reveal the possible anatomical basis ...
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Immobility accompanies the antinociception mediated by the rostral ventromedial medulla of the rat

Brain Research, 2000
The rostral ventromedial medulla (RVM) is part of a descending pain modulatory system that runs from the periaqueductal gray (PAG) to the spinal cord. The objective of the present study was to determine whether the antinociception mediated by the RVM is associated with locomotor changes as has been reported for the PAG [42]. Kainate (4, 20, or 40 pmol),
M M, Morgan, P K, Whitney
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Are opioid-sensitive neurons in the rostral ventromedial medulla inhibitory interneurons? [PDF]

Neuroscience, 2008
mu-Opioid agonists frequently activate output neurons in the brain via disinhibition, that is, by inhibiting "secondary cells," which results in disinhibition of "primary cells," considered to be output neurons. Secondary cells are generally presumed to be inhibitory interneurons that serve only to regulate the activity of the output neurons.
M M Heinricher, M M Heinricher
exaly   +3 more sources

Atypical on-, off- and neutral cells in the rostral ventromedial medulla oblongata in rat

Experimental Brain Research, 2002
It is generally assumed that the response pattern of on-, off- and neutral cells in the rostral ventromedial medulla (RVM) to noxious stimulation is independent of stimulation site. But recent studies have shown that a remarkable number of RVM neurons do not have whole-body receptive fields.
Cathrin, Schnell, Coskun, Ulucan, Jens, Ellrich   +2 more
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Circuitry Underlying Antiopioid Actions of Cholecystokinin Within the Rostral Ventromedial Medulla

Journal of Neurophysiology, 2001
It is now well established that the analgesic actions of opioids can be modified by “anti-analgesic” or “antiopioid” peptides, among them cholecystokinin (CCK). Although the focus of much recent work concerned with CCK-opioid interactions has been at the level of the spinal cord, CCK also acts within the brain to modify opioid analgesia. The aim of the
M M, Heinricher, S, McGaraughty, V, Tortorici   +2 more
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Kappa opioid receptors in the rostral ventromedial medulla of male and female rats

Journal of Comparative Neurology, 2006
AbstractKappa opioid receptor (KOR) ligands alter nociceptive responses when applied to the rostral ventromedial medulla (RVM). However, the effects of kappa opioid receptor ligands are distinct in males and females. The present study examined the distribution of kappa opioid receptor immunoreactivity in the RVM of male and female rats.
Carrie T, Drake, Andrew X, De Oliveira, Jonathan A, Harris, Denise M, Connor, Clayton W, Winkler, Sue A, Aicher   +5 more
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Orexin-A microinjection into the rostral ventromedial medulla causes antinociception on formalin test

Pharmacology Biochemistry and Behavior, 2014
Orexins are produced from neurons which are restricted to a few regions of the lateral hypothalamus (LH), where they are important in pain modulation. The orexin receptors and orexinergic projections are localized in regions previously shown to play a role in pain modulation such as rostral ventromedial medulla (RVM).
Hassan, Azhdari-Zarmehri, Saeed, Semnanian, Yaghoub, Fathollahi   +2 more
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Neurotensin Excites Periaqueductal Gray Neurons Projecting to the Rostral Ventromedial Medulla

Journal of Neurophysiology, 2001
Microinjection of neurotensin into the midbrain periaqueductal gray (PAG) produces a potent and naloxone-insensitive analgesic effect. To test the hypothesis that neurotensin induces the analgesic effect by activating the PAG-rostral ventromedial medulla (RVM) descending antinociceptive pathway, PAG neurons that project to RVM (PAG-RVM) were identified
A H, Li, H M, Hwang, P P, Tan, T, Wu, H L, Wang   +4 more
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