Results 131 to 140 of about 58,009 (170)
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Mu and kappa opioid receptors in periaqueductal gray and rostral ventromedial medulla
NeuroReport, 1998The periaqueductal gray (PAG) and rostral ventromedial medulla (RVM) are important brain stem pain modulating regions. Recent evidence suggests that kappa opioids antagonize the effects of mu opioids in the RVM. However, the anatomical relationship between mu and kappa opioid receptors in PAG and RVM is not well characterized.
H B, Gutstein +4 more
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Noradrenergic input to nociceptive modulatory neurons in the rat rostral ventromedial medulla
The Journal of Comparative Neurology, 1997Within the rostral ventromedial medulla (RVM), there are two classes of putative pain modulation neurons: ON cells and OFF cells, which respectively burst or pause prior to withdrawal reflexes elicited by noxious stimulation. Alpha-adrenergic agonists injected into the RVM produce changes in the latency of spinal nocifensive reflexes and, when ...
X W, Meng +4 more
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Dorsal horn projection targets of ON and OFF cells in the rostral ventromedial medulla
Journal of Neurophysiology, 19951. The rostral ventromedial medulla (RVM) participates in the modulation of nociceptive transmission by spinal cord neurons. Previous anatomic studies have demonstrated that RVM neurons project to laminae I, II, and V of the dorsal horn; laminae VII and VIII of the intermediate and ventral horns; the intermediolateral column; and lamina X.
H L, Fields, A, Malick, R, Burstein
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Neuroscience Letters, 1994
Triple microinjections of neurotensin (10 nmol each), which occupied a large volume of tissue within the nucleus reticularis gigantocellularis (Gi), produced an inhibition of the tail-flick reflex in awake rats. This effect was less than that previously observed by a single injection (10 nmol) into the nucleus raphe magnus (RMg) (see ref.
M O, Urban, D J, Smith
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Triple microinjections of neurotensin (10 nmol each), which occupied a large volume of tissue within the nucleus reticularis gigantocellularis (Gi), produced an inhibition of the tail-flick reflex in awake rats. This effect was less than that previously observed by a single injection (10 nmol) into the nucleus raphe magnus (RMg) (see ref.
M O, Urban, D J, Smith
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Regulation of Autonomic Cardiovascular Function by the Rostral Ventromedial Medulla
1991It is generally accepted that neural elements in the rostral ventral medulla (RVM) are essential for the neurogenic maintenance of arterial pressure. In recent years, the source of vasomotor tone in RVM has been ascribed to a small region in the lateral RVM lying just caudal to the posterior pole of the facial nucleus.
Kurt J. Varner +6 more
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Biphasic Modulation of Visceral Nociception by Neurotensin in Rat Rostral Ventromedial Medulla
The Journal of Pharmacology and Experimental Therapeutics, 1999A potential role for neurotensin in the rostral ventromedial medulla (RVM) in modulation of visceral nociceptive transmission was examined in this study. Microinjection of neurotensin (3-3000 pmol) into the RVM of awake rats produced a dose-dependent inhibition of the visceromotor response (VMR) to noxious colorectal distension (CRD) that lasted 30 to ...
M O, Urban, S V, Coutinho, G F, Gebhart
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The ‘in’s and out’s’ of descending pain modulation from the rostral ventromedial medulla
Trends in NeurosciencesThe descending-pain modulating circuit controls the experience of pain by modulating transmission of sensory signals through the dorsal horn. This circuit's key output node, the rostral ventromedial medulla (RVM), integrates 'top-down' and 'bottom-up' inputs that regulate functionally defined RVM cell types, 'OFF-cells' and 'ON-cells', which ...
Caitlynn C, De Preter +1 more
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Effects of acetylsalicylic acid and morphine on neurons of the rostral ventromedial medulla in rat
Neuroscience Research, 2003Morphine exerts its analgesic effect via the endogenous pain control system consisting of the periaqueductal grey (PAG) and the rostral ventromedial medulla (RVM). Acetylsalicylic acid (ASA) may also act via this system, but so far this has only been demonstrated for the inhibitory effect on the tail-flick reflex with extremely high doses (200-300 mg ...
Coskun, Ulucan +3 more
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NK-1 Receptors Modulate the Excitability of
The role of neurokinin-1 (NK-1) receptors in the rostral ventromedial medulla (RVM) was studied using extracellular single-unit recording combined with microiontophoresis. In rats, on- and off-type neurons were identified using noxious heat or mechanical stimuli applied to the tail. Responses evoked by iontophoretic application of N-methyl-d-aspartate
Dénes, Budai +3 more
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Brain Research, 2008
We have previously shown that the extracellular signal-regulated kinase (ERK) is activated in the rostral ventromedial medulla (RVM) during peripheral inflammation. In the present study, the relationship between ERK signaling in the RVM and pain hypersensitivity was investigated in the rat.
Hiroki, Imbe +6 more
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We have previously shown that the extracellular signal-regulated kinase (ERK) is activated in the rostral ventromedial medulla (RVM) during peripheral inflammation. In the present study, the relationship between ERK signaling in the RVM and pain hypersensitivity was investigated in the rat.
Hiroki, Imbe +6 more
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