Results 61 to 70 of about 2,517,805 (293)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Design and Vibration Characteristic Analysis of Piezoelectric Micro Oil-Supply Device

Applied Sciences
In response to the lubrication failure problem during spacecraft operation, new requirements have been put forward for micro, precise, and dynamically adjustable lubrication and oil-supply technology for its key moving components. This article charts the
Zhaoliang Dou, Jianfang Da, Gang Zhou, Shaohua Zhang, Lu Gao, Fengbin Liu   +5 more
doaj   +1 more source

Rotational Elasticity [PDF]

The Quarterly Journal of Mechanics and Applied Mathematics, 2011
We consider an infinite 3-dimensional elastic continuum whose material points experience no displacements, only rotations. This framework is a special case of the Cosserat theory of elasticity. Rotations of material points are described mathematically by attaching to each geometric point an orthonormal basis which gives a field of orthonormal bases ...
Vassiliev, Dmitri, Downes, Robert J., Boehmer, Christian   +2 more
openaire   +3 more sources

Rotating Alfvén waves in rotating plasmas

Journal of Plasma Physics, 2023
Angular momentum coupling between a rotating magnetized plasma and torsional Alfvén waves carrying orbital angular momentum (OAM) is examined. It is demonstrated not only that rotation is the source of Fresnel–Faraday rotation – or orbital Faraday rotation effects – for OAM-carrying Alfvén waves, but also that angular momentum from an OAM-carrying ...
J.-M. Rax, R. Gueroult, N.J. Fisch
openaire   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Assimilation and return of nutrient elements by plants in soil and impact of crop residues on soil fertility in short cotton rotations

Растениевъдни науки, 2015
To develop a highly efficient the short cycled rotations which provide conservation and improvement soil fertility, of Silt Loam Calcic Xerosol (FAO, 2003) of Tashkent region and the results of the investigations recommend and inculcate to agricultural ...
Abdulaly Iminov, Fazliddin Namazov, Bakhodir Khalikov   +2 more
doaj  

Arthroscopic ankle fusion in haemophilic ankle arthropathy: A report of four cases and narrative literature review

Journal of Orthopaedic Reports
Background: The first aim of this study was to report the authors’ experience in the last 10 years, for arthroscopic ankle fusion in haemophilic ankle arthropathy.
Fitzgerald Chukwuemeka Anazor, Vusumuzi Sibanda, Crispin Southgate, Baljinder Dhinsa   +3 more
doaj   +1 more source

Revealing Cosmic Rotation

, 2012
Cosmological Birefringence (CB), a rotation of the polarization plane of radiation coming to us from distant astrophysical sources, may reveal parity violation in either the electromagnetic or gravitational sectors of the fundamental interactions in ...
Amit P. S. Yadav, B. Reichborn-Kjennerud, Brian G. Keating, D. Baumann, J. J. McMahon, K. M. Smith, K. W. Yoon, Meir Shimon   +7 more
core   +2 more sources

Rotation r-graphs

Discrete Mathematics, 2023
We study rotation $r$-graphs and show that for every $r$-graph $G$ of odd regularity there is a simple rotation $r$-graph $G'$ such that $G$ can be obtained form $G'$ by a finite number of $2$-cut reductions. As a consequence, some hard conjectures as the (generalized) Berge-Fulkerson Conjecture and Tutte's 3- and 5-flow conjecture can be reduced to ...
Eckhard Steffen, Isaak H. Wolf
openaire   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source