Results 71 to 80 of about 1,093,749 (248)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Unmanned Aerial Vehicle-Based Techniques for Monitoring and Prevention of Invasive Apple Snails (Pomacea canaliculata) in Rice Paddy Fields

Agriculture
The destructive impact of invasive apple snail (Pomacea canaliculata) on young rice seedlings has garnered global attention, particularly in warm regions where rice production occurs.
Senlin Guan, Kimiyasu Takahashi, Shunichiro Watanabe, Katsunori Tanaka   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

THE ECONOMIC IMPORTANCE OF CROP ROTATION SYSTEMS: EVIDENCE FROM THE LITERATURE [PDF]

Agricultural sustainability requires that the individual farm firm be competitive and profitable while simultaneously enhancing environmental quality and the natural resource base upon which the farm firm and agricultural economy depends. The reliance of
Schwab, Gerald, Gebremedhin, Berhanu
core  

Supernumerary teeth in the premaxillary region: its effects on the eruption and occlusion of the permanent incisors

Australasian Orthodontic Journal, 1990
The presence of supernumerary teeth in the premaxillary region may cause a variety of pathological effects. This study was carried out to determine the various aspects of supernumerary teeth in the premaxillary region, particularly the effects of the ...
Nik-Hussein Nik Noriah
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Abordar la ciudad. Algunas estrategias transformadoras para el análisis urbano (entrevistas con Joan Mac Donald, Observatorio Metropolitano y Left Hand Rotation)

Encrucijadas: Revista Crítica de Ciencias Sociales, 2012
Joan Mac Donald es arquitecta especializada en políticas y programas de asentamientos humanos. Ha sido viceministra de Vivienda y urbanismo en Chile entre 1990 y 1994.
David Prieto, Joan Mac Donald, Left Hand Rotation, Obervatorio Metropolitano   +3 more
doaj  

Development of a Simulation System with Integrated In Situ Monitoring Capabilities for the Lubrication State of Rolling Elements in Space Control Moment Gyro Bearings

Lubricants
As a core actuator for attitude control in spacecraft, the lubrication state of the bearing rolling elements in the Control Moment Gyro (CMG) critically determines the operational lifetime and control accuracy of the overall assembly.
Zhaoliang Dou, Zhuangzhuang Du, Saihang Zhou, Gang Zhou, Shaohua Zhang, Lu Gao, Ye Yang, Fengbin Liu   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Impact of Auditor Rotation on the Audit Quality: A Field Study from Egypt [PDF]

Lack of audit quality and subsequent audit failures result mainly from a lack of independence which is considered to be a consequence of the extended auditor client relationship.
Diana Mostafa, Magda Hussien
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