Results 81 to 90 of about 2,492,535 (278)

New Technique: A Novel Femoral Derotation Osteotomy for Malrotation following Intramedullary Nailing

Case Reports in Orthopedics, 2012
A 19-year-old female patient sustained a closed spiral midshaft femoral fracture and subsequently underwent femoral intramedullary nail insertion. At followup she complained of difficulty in walking and was found to have a unilateral in-toeing gait.
S. Jagernauth, A. J. Tindall, S. Kohli, P. Allen   +3 more
doaj   +1 more source

Defective wing development in black-headed gull (Larus ridibundus) - case report

Veterinární Medicína, 2003
In 2000-2001 juvenile individuals of black-headed gull (Larus ridibundus) were repeatedly found in a Nadeje fishpond system in the Trebon Basin Area that were incapable of flying, with deformed wings.
J. Rajchard, V. Rajchard
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A simple novel technique for closure of simple and complex pilonidal sinus with either simple (tongueshaped) or bilobed rotation fl ap

Indian Journal of Plastic Surgery, 2007
Background:Pilonidal sinus is a common disease in young adults that carries high postoperative morbidity and patients′ discomfort; controversy still exists regarding the best surgical technique for the treatment of the disease.
M.S. Awad Mohamed, Tolba Mohamed, H. Gharib Osama   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Upside-Down Rotation of a Breast Implant with Double Capsule Formation after Aesthetic Breast Augmentation: A Case Report [PDF]

Archives of Aesthetic Plastic Surgery, 2018
Some complications can occur after augmentation mammoplasty with a prosthesis. Double capsule formation is an uncommon complication, and it is especially rare for it to be accompanied by malrotation of a round implant.
Wang Seok Lee, Sang Gue Kang
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Effects of Uniform and Differential Rotation on Stellar Pulsations

, 2008
We have investigated the effects of uniform rotation and a specific model for differential rotation on the pulsation frequencies of 10 \Msun\ stellar models. Uniform rotation decreases the frequencies for all modes.
Antia, Baglin, Basu, Belmonte, C. C. Lovekin, Carcofi, Christensen-Dalsgaard, Clement, Couvidat, Eff-Darwich, Gillich, Hacking, Jackson, Lovekin, M. J. Clement, R. G. Deupree, Schou, Smith, Stoeckley, Tassoul, Zahn   +20 more
core   +2 more sources

ROTATING GLOBULAR CLUSTERS [PDF]

The Astrophysical Journal, 2013
Internal rotation is considered to play a major role in the dynamics of some globular clusters. However, in only few cases it has been studied by quantitative application of realistic and physically justified global models. Here we present a dynamical analysis of the photometry and three-dimensional kinematics of omega Cen, 47 Tuc, and M15, by means of
P. Bianchini, A.L. Varri, G. Bertin, A. Zocchi   +3 more
openaire   +2 more sources