Results 61 to 70 of about 696,003 (270)

Rotavirus Genotypes in Hospitalized Children with Acute Gastroenteritis before and after Rotavirus Vaccine Introduction in Blantyre, Malawi, 1997-2019 [PDF]

, 2022
Background: Rotavirus vaccine (Rotarix [RV1]) has reduced diarrhea-associated hospitalizations and deaths in Malawi. We examined the trends in circulating rotavirus genotypes in Malawi over a 22-year period to assess the impact of RV1 introduction on ...
Mandolo, Jonathan J, Kanjerwa, O, Jere, KC, Chinyama, E, Chinyama, End, Shawa, Isaac T, Jere, Khuzwayo C, Kamng’ona, A.W, Barnes, KG, Barnes, K.G, Pitzer, VE, Shawa, IT, Parashar, UD, Parashar, U.D, Cunliffe, N.A, Chaguza, C, Nyaga, Martin M, Pitzer, Virginia E, Mhango, C, Kamng'ona, Arox W, Mandolo, J.J, Matambo, P.B, Jere, K.C, Nyaga, M.M, Wachepa, R, Cunliffe, NA, Hungerford, Daniel, Kanjerwa, Oscar, Iturriza-Gomara, M, Shawa, I., Pitzer, V.E, Chaguza, Chrispin, Parashar, Umesh D, Kamngona, AW, Matambo, Prisca B, Mhango, Chimwemwe, Malamba-Banda, Chikondi, Mandolo, JJ, Nyaga, MM, Hungerford, D, Wachepa, Richard, Cunliffe, Nigel A, Matambo, PB, Malamba-Banda, C, Barnes, Kayla G, Iturriza-Gomara, Miren   +45 more
core   +1 more source

Religious and community leaders’ acceptance of rotavirus vaccine introduction in Yogyakarta, Indonesia: a qualitative study

BMC Public Health, 2019
BackgroundIn Indonesia, oral rotavirus vaccines are available but not funded on the National Immunization Program (NIP). New immunization program introduction requires an assessment of community acceptance. For religiously observant Muslims in Indonesia,
R. Padmawati, A. Heywood, M. Sitaresmi, J. Atthobari, C. R. Macintyre, Y. Soenarto, H. Seale   +6 more
semanticscholar   +1 more source

Detection of Novel Rotavirus Strain by Vaccine Postlicensure Surveillance

Emerging Infectious Diseases, 2013
Surveillance for rotavirus-associated diarrhea after implementation of rotavirus vaccination can assess vaccine effectiveness and identify disease-associated genotypes.
Geoffrey A. Weinberg, Elizabeth N. Teel, Slavica Mijatovic-Rustempasic, Daniel C. Payne, Sunando Roy, Kimberly Foytich, Umesh D. Parashar, Jon R. Gentsch, Michael D. Bowen   +8 more
doaj   +1 more source

Rotavirus Vaccines

Indian Journal of Medical Microbiology, 2006
Rotavirus, the most common cause of severe diarrhea and a leading cause of mortality in children, has been a priority target for vaccine development for the past several years. The first rotavirus vaccine licensed in the United States was withdrawn because of an association of the vaccine with intussusception.
openaire   +2 more sources

Estimated impact of rotavirus vaccine on hospitalizations and deaths from rotavirus diarrhea among children <5 in Asia

Expert Review of Vaccines, 2018
Background: Of the 215,000 global deaths from rotavirus estimated in 2013, 41% occur in Asian countries. However, despite a recommendation for global rotavirus vaccination since 2009, only eight countries in Asia have introduced the rotavirus vaccine ...
Eleanor Burnett, Jacqueline E. Tate, Carl D. Kirkwood, E. Anthony S. Nelson, Mathuram Santosham, A. Duncan Steele, Umesh D. Parashar   +6 more
doaj   +1 more source

Rotavirus vaccines: an overview [PDF]

Clinical Microbiology Reviews, 1996
Rotavirus vaccine development has focused on the delivery of live attenuated rotavirus strains by the oral route. The initial "Jennerian" approach involving bovine (RIT4237, WC3) or rhesus (RRV) rotavirus vaccine candidates showed that these vaccines were safe, well tolerated, and immunogenic but induced highly variable rates of protection against ...
K, Midthun, A Z, Kapikian
openaire   +2 more sources

Global rotavirus vaccine introductions and coverage: 2006 – 2016

Human Vaccines & Immunotherapeutics, 2018
An estimated 215,000 children died of rotavirus infections in 2013, accounting for 37% of diarrhea-related deaths worldwide, 92% of which occurred in low and lower-middle income countries. Since 2009 the World Health Organization (WHO) recommends the use
Alice J. Abou-Nader, Molly A. Sauer, A. Duncan Steele, Jacqueline E. Tate, Deborah Atherly, Umesh D. Parashar, Mathuram Santosham, E. Anthony S. Nelson   +7 more
doaj   +1 more source

A randomized Phase III clinical trial to assess the efficacy of a bovine-human reassortant pentavalent rotavirus vaccine in Indian infants

Vaccine, 2017
Highlights • Pentavalent reassortant rotavirus vaccine was tested for efficacy in infants.• The vaccine (BRV-PV) showed excellent tolerability and a good safety profile.• Primary analysis efficacy was 36% against SRVGE and up to 60.5% against VSRVGE ...
P. Kulkarni, S. Desai, T. Tewari, A. Kawade, Nidhi Goyal, B. Garg, Dinesh Kumar, S. Kanungo, Veena Kamat, G. Kang, A. Bavdekar, S. Babji, Sanjay Kamlakar Juvekar, B. Manna, S. Dutta, Rama Angurana, Deepika Dewan, Abhijeet Dharmadhikari, Jagdish K Zade, R. Dhere, A. Fix, M. Power, Vidyasagar Uprety, Varsha Parulekar, I. Cho, T. R. Chandola, Vikash K. Kedia, A. Raut, J. Flores, Hanif Lalit Rakesh Mohd. Alok Farhana Subodh S. Chetna H Shaikh Gupta Patil Aslam Arya Rafiqi Gupta Maliye , Hanif Shaikh, Lalit R. Gupta, Rakesh Patil, M. Aslam, A. Arya, F. Rafiqi, Subodh S. Gupta, C. Maliye, P. Bahulekar, K. Bala, Tajali Nazir Shora, Shahid Hussain, Mihir Kumar Bhattacharya, A. Mukhopadhyay, Dilip Kumar Pal, Jayanta Saha, Ranjitha S. Shetty, Muralidhar M. Kulkarni, Ch.Vamshi Raj   +48 more
semanticscholar   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Influence of the intestinal microbiota on the immunogenicity of oral rotavirus vaccine given to infants in south India

Vaccine, 2018
Oral rotavirus vaccines have consistently proven to be less immunogenic among infants in developing countries. Discrepancies in the intestinal microbiota, including a greater burden of enteropathogens and an altered commensal community composition, may ...
E. Parker, Ira Praharaj, A. Zekavati, R. Lazarus, S. Giri, Darwin J. Operario, Jieng-Lung Liu, E. Houpt, M. Iturriza-Gómara, B. Kampmann, J. John, G. Kang, N. Grassly   +12 more
semanticscholar   +1 more source