Estimating the global impact of rotavirus vaccines on child mortality [PDF]
International Journal of Infectious Diseases, 2023 Objectives: We estimated the global impact of rotavirus vaccines on deaths among children under five years old by year. Methods: We used a proportionate outcomes model with a finely disaggregated age structure to estimate rotavirus deaths prevented by ...
Andrew Clark +10 more
doaj +3 more sources
The Challenges and Opportunities of Next-Generation Rotavirus Vaccines: Summary of an Expert Meeting with Vaccine Developers [PDF]
Viruses, 2022 The 2nd Next Generation Rotavirus Vaccine Developers Meeting, sponsored by PATH and the Bill and Melinda Gates Foundation, was held in London, UK (7–8 June 2022), and attended by vaccine developers and researchers to discuss advancements in the ...
Jessie Chen +5 more
doaj +3 more sources
The performance of licensed rotavirus vaccines and the development of a new generation of rotavirus vaccines: a review [PDF]
Human Vaccines & Immunotherapeutics, 2021 Rotavirus, which causes acute gastroenteritis and severe diarrhea, has posed a great threat to children worldwide over the last 30 y. Since no specific drugs and therapies against rotavirus are available, vaccination is considered the most effective ...
Yuxiao Wang +3 more
doaj +3 more sources
Product review of the rotavirus vaccines ROTASIIL, ROTAVAC, and Rotavin-M1 [PDF]
Human Vaccines & Immunotherapeutics, 2021 Rotavirus is the leading cause of severe dehydrating gastroenteritis and death due to diarrhea among children under 5, causing over 180,000 under-5 deaths annually.
Annika Skansberg +4 more
doaj +3 more sources
Overview of the Development, Impacts, and Challenges of Live-Attenuated Oral Rotavirus Vaccines [PDF]
Vaccines, 2020 Safety, efficacy, and cost-effectiveness are paramount to vaccine development. Following the isolation of rotavirus particles in 1969 and its evidence as an aetiology of severe dehydrating diarrhoea in infants and young children worldwide, the quest to ...
Olufemi Samuel Folorunso +1 more
doaj +3 more sources
Lessons Learned and Future Perspectives for Rotavirus Vaccines Switch in the World Health Organization, Regional Office for Africa. [PDF]
Vaccines (Basel), 2023 Background: Following the World Health Organization (WHO) recommendation, 38/47 countries have introduced rotavirus vaccines into the program of immunization in the WHO Regional Office for Africa (WHO/AFRO).
Mandomando I +5 more
europepmc +2 more sources
Global Experience With Rotavirus Vaccines. [PDF]
J Infect Dis, 2021 Rotavirus is a major cause of severe pediatric diarrhea worldwide. In 2006, 2 live, oral rotavirus vaccines, Rotarix and RotaTeq, were licensed for use in infants and were rapidly adopted in many high- and middle-income settings where efficacy had been ...
Burke RM, Tate JE, Parashar UD.
europepmc +2 more sources
Rotavirus vaccines: progress and new developments. [PDF]
Expert Opin Biol Ther, 2022 Introduction Rotavirus is the primary cause of severe acute gastroenteritis among children under the age of five globally, leading to 128,500 to 215,000 vaccine-preventable deaths annually. There are six licensed oral, live-attenuated rotavirus vaccines:
Cates JE, Tate JE, Parashar U.
europepmc +2 more sources
Potential impact and cost-effectiveness of injectable next-generation rotavirus vaccines in 137 LMICs: a modelling study. [PDF]
Hum Vaccin Immunother, 2022 While current live, oral rotavirus vaccines (LORVs) are reducing severe diarrhea everywhere, their effectiveness is lower in high burden settings. Alternative approaches are in advanced stages of clinical development, including injectable next-generation
Debellut F +3 more
europepmc +2 more sources
Vaccine, 2022 Rotavirus remains a leading cause of diarrhoeal morbidity and mortality in young children and rotavirus vaccines are critical for reducing global disease burden.
Henschke N +8 more
europepmc +2 more sources