Tephrosin Suppresses the Chemoresistance of Paclitaxel-Resistant Ovarian Cancer via Inhibition of FGFR1 Signaling Pathway [PDF]
Biomedicines, 2023 Ovarian cancer is the leading cause of death among gynecologic cancers. Paclitaxel is used as a standard first-line therapeutic agent for ovarian cancer.
Hee Su Kim +6 more
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UHPLC-MS/MS-GNPS based phytochemical investigation of Dryopteris ramosa (Hope) C. Chr. and evaluation of cytotoxicity against liver and prostate cancer cell lines [PDF]
Heliyon, 2022 Dryopteris ramosa (family; Dryopteridaceae) has been reported for its medicinal importance in cancer, gastrointestinal disorders, and infections. The present study aimed to investigate the detailed phytochemical profile of D.
Zia-ur-Rehman +7 more
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FEBS Open Bio, 2022 We previously isolated derrisfolin A, a novel rotenoid derivative, from the stems of Derris trifoliata Lour. (Leguminosae). Here, we report that derrisfolin A induces the expression of endogenous regucalcin (RGN) protein in both pancreatic MIN6 β‐cells ...
Tomiyasu Murata +9 more
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Research on the Hormonomics of Three Lilium Species and Their Flavonoid Diversification and Specificity [PDF]
AntioxidantsHormonomics represents an innovative approach to plant physiology and biochemistry. We utilized hormonomics to analyze the hormone profiles of three lily bulbs.
Xuanyu He +12 more
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11-(3-Chloro-2-hydroxypropoxy)-2,3,9-trimethoxychromeno[3,4-b]chromen-12(6H)-one
Acta Crystallographica Section E, 2009 In the title compound, C22H21ClO8, the rotenoid core is nearly planar (r.m.s. deviation 0.114 Å), with the largest deviations from the least-squares plane being 0.286 (3) and 0.274 (2) Å.
Supranee Sangthong +4 more
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Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat. [PDF]
PLoS ONE, 2012 The main goal of adequate organ preservation is to avoid further cellular metabolism during the phase of ischemia. However, modern preservation solutions do rarely achieve this target.
Patrick Paulus +8 more
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Chitosan nanocomposite containing rotenoids: an alternative bioinsecticidal approach for the management of Aedes aegypti [PDF]
Beilstein Journal of NanotechnologyClimate change has intensified the proliferation of disease vectors, such as Aedes aegypti, the primary transmitter of dengue, chikungunya, and zika viruses.
Maria A. A. Bertonceli +13 more
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Ethnomedicinal values of Boerhaavia diffusa L. as a panacea against multiple human ailments: a state of art review [PDF]
Frontiers in Chemistry, 2023 Ethnopharmacological relevance: Therapeutic botanicals (plants and derivatives) are in use since antiquity for various health ailments. The ethnic community is the repository of the information, the multifactorial therapeutic applications of which may ...
Sarita Das +7 more
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Rotenone and Its Derivative, Rotenoisin A, Induce Neurodegeneration Differentially in SH-SY5Y Cells [PDF]
BiomedicinesRotenone (ROT), the most significant rotenoid, which has shown anticancer activity, has also been reported to be toxic to normal cells, inducing Parkinson’s disease (PD)-like neuronal loss with aggregation of α-synuclein (α-syn).
Mahesh Ramalingam +6 more
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Antioxidant Chemistry of Phenolics in Chinese Herbal Medicines: A Holism-Based Review. [PDF]
Chem BiodiversPhenolic antioxidants in CHMs mainly include chalcone, stilbene, flavonoid, xanthone, and Diels–Alder‐type adducts. They undergo direct and indirect pathways to exert antioxidant action. The indirect pathway is transition metal‐chelating, while the direct pathway comprises several redox‐based reactions (e.g., SET and HAT) and RAF reactions.
Li X.
europepmc +2 more sources