Results 191 to 200 of about 64,618 (285)

CSDE1 Drives Glycolysis and the Progression of Prostate Cancer Through RAC1‐Dependent RAS/MAPK Activation

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
The mechanism by which CSDE1 promotes prostate cancer progression through RAC1‐dependent RAS/MAPK activation and enhanced glycolysis. ABSTRACT Prostate cancer (PCa) remains a leading cause of cancer‐related morbidity and mortality among men, necessitating the elucidation of molecular drivers behind its progression.
Zhen Yin, Zefeng Wang, Wei Gong, Zitao Wang, Zongze Li, Lizhe Xu, Jinzhuo Ning, Lei Gao, Tiejun Pan, Weimin Yu, Yu Zhou, Jinbo Sun, Fan Cheng   +12 more
wiley   +1 more source

Reduced levels of nitrated α-synuclein in the protective effect of harpagoside on rotenone-induced cellular models of Parkinson's disease. [PDF]

Front Cell Dev Biol
Lang J, Xiong Z.
europepmc   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

Parkinson's associated protein DJ-1 regulates intercellular communication via extracellular vesicles in oxidative stress. [PDF]

Cell Death Discov
Page T, Musi CA, Bakker SE, Jenkins DR, Hill EJ, Borsello T, Milic I, Devitt A, Repici M.   +8 more
europepmc   +1 more source

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source

Farnesol, a Dietary Sesquiterpene, Attenuates Rotenone-Induced Dopaminergic Neurodegeneration by Inhibiting Oxidative Stress, Inflammation, and Apoptosis via Mediation of Cell Signaling Pathways in Rats. [PDF]

Int J Mol Sci
Bader Eddin L, Arunachalam S, Azimullah S, Nagoor Meeran MF, Alshehhi MAHA, Mahgoub A, Beiram R, Ojha S.   +7 more
europepmc   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, Volume 13, Issue 16, 18 March 2026.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Off-target effects of mitochondrial oxidative phosphorylation inhibitors are common and can compromise the viability of cultured cells. [PDF]

Mitochondrial Commun
Kozhukhar N, Alexeyev MF.
europepmc   +1 more source

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source

The succinate prodrug NV354 prevents brain lesions and late-stage motor dysfunction in mitochondrial complex I deficiency. [PDF]

iScience
McManus MJ, Zhu Y, Alves C, Kohli N, Prada-Dacasa P, Sanchez-Benito L, Sanz E, Yee I, Robinson L, Sheldon M, McHugh WJ, Ranganathan A, Meng J, Duncan N, Grönberg A, Wallace DC, Piel S, Karlsson M, Moss SJ, Webster L, Hansson MJ, Elmér E, Ehinger JK, Quintana A, Kilbaugh TJ.   +24 more
europepmc   +1 more source