Results 191 to 200 of about 38,087 (260)

Vaccination Drives Alveolar Macrophages Pool Remodeling via Training Resident Cells and Recruiting Monocyte‐Derived Cells to Defend Against Multidrug‐Resistant Acinetobacter baumannii

MedComm, Volume 7, Issue 8, August 2026.
Under homeostatic conditions, the lungs primarily harbor tissue‐resident alveolar macrophages (TR‐AMs). Intranasal immunization with A. baumannii IWC remodels the alveolar macrophage pool via two complementary mechanisms: recruitment and progressive differentiation of CD11B+CD13+ monocyte‐derived AMs, together with direct functional and epigenetic ...
Xiaomin Zhang, Yangyang Zhou, Chuanying Xiang, Ning Wang, Yan Li, Kai Chen, Yu Xie, Hong Yang, Xiangcheng Sun, Yun Shi   +9 more
wiley   +1 more source

Resmetirom Ameliorates Fibrogenesis in Hepatic Stellate Cells via Thyroid Hormone Receptor Alpha‐Fatty‐Acid Amide Hydrolase 1 Signaling Pathway

MedComm, Volume 7, Issue 8, August 2026.
1. Resmetirom attenuates the activation of HSCs induced in in vitro and in vivo models. 2. Resmetirom attenuates the activation of HSCs through its specific action on the thyroid hormone receptor alpha. 3. Resmetirom requires fatty‐acid amide hydrolase 1 to reduce HSC activation. ABSTRACT Resmetirom is a liver‐directed, thyroid hormone receptor β (THRβ)
Eva Novoa, Alba Cabaleiro, Borja López‐Picallo, Natalia da Silva Lima, Cristina Riobello, Carmen Pena, Jose Iglesias‐Moure, Ana Senra, Maria Luz Martínez‐Chantar, Anabel Fernandez‐Iglesias, Jordi Gracia‐Sancho, Susana Bravo, Carlos Dieguez, Marta Varela‐Rey, Vincent Prevot, Markus Schwaninger, Miguel López, Rubén Nogueiras   +17 more
wiley   +1 more source

Neuroprotective Effect of Cannabidiol Against Rotenone in Hippocampal Neuron Culture. [PDF]

Chem Asian J
Yang S, Choi H, Kim J, Choi IS.
europepmc   +1 more source

Activation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging

Aging Cell, Volume 25, Issue 8, August 2026.
Skeletal muscle aging is associated with a decrease in expression of the lactate receptor GPR81. Treating senescent myoblasts in vitro and progeric mice in vivo with GPR81 agonist decreases intramyocellular lipid accumulation and reverses hallmarks of aging. ABSTRACT Skeletal muscle aging is associated with increased lipid accumulation, or myosteatosis,
Pihu Mehrotra, Sai Harsha Bhamidipati, Pedro Lei, John Toftegaard, Debanik Choudhury, Maryam Elsayed, Yali Zhang, Jianmin Wang, Shweta Chitkara, G. Ekin Atilla‐Gokcumen, Song Liu, Stelios T. Andreadis   +11 more
wiley   +1 more source

Report on Rotenone

Journal of AOAC INTERNATIONAL, 1952
openaire   +1 more source

Endothelial AGGF1 Deficiency Causes Mitochondrial Dysfunction and Contributes to Age‐Elevated Blood Pressure

Aging Cell, Volume 25, Issue 8, August 2026.
Endothelial AGGF1 deficiency contributes to early vascular aging and age‐elevated blood pressure via inhibiting the SESN2/p‐eNOS pathway. Age‐dependent AGGF1 attenuation reduces its binding to the SESN2 promoter. SESN2 downregulation induces mitochondrial respiratory dysfunction and elevated mitochondrial ROS, thereby reducing eNOS phosphorylation ...
Weixin Lv, Xiaojuan Zhong, Qiang Yuan, Xueting Gong, Ya Zhao, Shilin Zhang, Andong Wu, Ming Wan, Xueer Li, Yangyi Zheng, Jiankun Liu, Bingbing Zhou, Yuanzheng Zhu, Limin Zhao, Qiquan Wang, Yang Xiang, Xiao‐Li Tian   +16 more
wiley   +1 more source

Distinct Ca²⁺ pools regulate NADPH oxidase 2 activation driving Ca²⁺-independent mitochondrial ROS formation and mitochondrial permeability transition in arsenic trioxide-treated NB4 cells. [PDF]

Arch Toxicol
Guidarelli A, Spina A, Buffi G, Fiorani M, Cantoni O.   +4 more
europepmc   +1 more source

Mitochondrial Adaptations in Skeletal Muscle Following Incretin-Based Therapies: In Vitro. [PDF]

J Cachexia Sarcopenia Muscle
Old V, Davies M, Denniff M, Choudhary P, Eastley N, Ashford RU, Watson E.   +6 more
europepmc   +1 more source

Dual Neuroprotective and Nephroprotective Effects of <i>Mucuna pruriens</i>, <i>Moringa oleifera</i>, and <i>Silybum marianum</i> (Milk Thistle) via Modulation of PI3K/AKT/mTOR and Nrf2/NF-κB Pathways in a Murine Comorbid PD-AKI Model. [PDF]

Int J Mol Sci
Al Housseini I, Dakdouk H, El Natour H, Borjac J.   +3 more
europepmc   +1 more source

TMBIM6 enhances dopaminergic neuron survival by modulating the IRE1a pathway in Parkinson's disease. [PDF]

Cell Death Dis
Ahumada-Montalva P, Muñoz-Carvajal F, Bórquez-Macaya S, Arévalo-Ramírez N, Cisternas-Olmedo M, Jerez C, Urbina-Muñoz V, Gomez W, Urrutia PJ, Hirsch EC, Ahumada M, Barrias P, Muñoz-Yañez C, Herrera-Vásquez A, Arriagada G, Woehlbier U, Calegaro-Nassif M, Sanhueza M, Vidal RL, Rojas-Rivera D.   +19 more
europepmc   +1 more source