Results 201 to 210 of about 65,398 (283)

Gabpα‐Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat

Advanced Science, Volume 13, Issue 8, 9 February 2026.
This study identifies the Gabpα–Pparγ complex as a key transcriptional regulator that couples glycolysis to lactate‐driven thermogenesis in brown adipose tissue by directly activating Eno1 transcription. ‌Competitive disruption of this interaction impairs lactate metabolism and thermogenic capacity.
Zhihan Wang, Huanyu Wang, Qianqian Kang, Ruping Pan, Rui He, Min Yang, Jiadai Liu, Xuemin Peng, Yuyu Xie, Hongyan Deng, Wenshe Wang, Zengzhe Zhu, Jing Ge, Yulian Liu, Ronghui Gao, Yaming Guo, Peng Yu, Limeng Pan, Danpei Li, Pema Maretich, Xiaoping Luo, Xuefeng Yu, Yong Chen   +22 more
wiley   +1 more source

Antistunting potential of deepsea water concentrate as multivitamin granules: stability and in vivo activity study. [PDF]

Sci Rep
Hartesi B, Retnoaji B, Sriwidodo S, Wardhana YW, Muhaimin M, Dewi MK, Muttaqien SE, Chaerunisaa AY.   +7 more
europepmc   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

Tubulin hyperacetylation drives HMGB1 nuclear exit via the ROS-PARP1 axis, leading to rotenone-induced G2/M arrest. [PDF]

J Biol Chem
Dutta S, Chakraborty S, Ghosh A, Halder P, Majumder S, Paul R, Nath S, Mukherjee P.   +7 more
europepmc   +1 more source

High‐mobility Group Protein 1/ Receptor for Advanced Glycation End Products/ Nuclear Factor‐κB Signalling Pathway Contributes to the Pathogenic Process of Striatal Neuron Impairment in the Rat Model of Parkinson's Disease

Brain and Behavior, Volume 16, Issue 2, February 2026.
In Parkinson's disease, the death of dopamine neurons in the substantia nigra, resulting in a decrease in dopamine levels in the striatum. This leads to striatal damage through the HMGB1/RAGE/NF‐κB signaling pathway, thereby inducing motor and cognitive dysfunction.
Yaofeng Zhu, Zean Du, Liping Sun, Ziyun Huang, Linju Jia, Tao Chen, Xuefeng Zheng, Wanlong Lei   +7 more
wiley   +1 more source

Correction: Thomas Broome, S.; Castorina, A. Systemic Rotenone Administration Causes Extra-Nigral Alterations in C57BL/6 Mice. <i>Biomedicines</i> 2022, <i>10</i>, 3174. [PDF]

Biomedicines
Thomas Broome S, Castorina A.
europepmc   +1 more source

Molecular Mechanisms and Therapeutic Potential of DJ‐1 in Skeletal Muscle Homeostasis and Disease

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
DJ‐1 protein functions as a redox‐sensing guardian in skeletal muscle by coordinating antioxidant defense, mitochondrial homeostasis, metabolic adaptation, and anti‐atrophy signaling. Enhancing its function holds promise as a potential therapeutic strategy for muscle atrophy, ALS, and metabolic myopathies.
Yue Zhang, Menghuan Li, Xiaojing Xie, Baokai Tian, Zhenwei Bao, Xuejie Yi   +5 more
wiley   +1 more source

Concentration-dependent effects of bacterial melanin on new superoxide-producing associates in rat tissues: a rotenone neurotoxic model of parkinson's disease. [PDF]

BMC Pharmacol Toxicol
Danielyan M, Karapetyan K, Simonyan R, Simonyan G, Babayan M, Poghosyan M, Yekmalyan H, Simonyan M, Simonyan K, Nebogova K.   +9 more
europepmc   +1 more source

ATGL From iWAT and BAT Is Crucial for Cardiac Remodeling and Metabolism After Myocardial Ischemia/Reperfusion

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Cardiac I/R activates adipose tissue. iatATGL‐KO increases adipocyte size and reduces lipogenesis in WAT, induces whitening and inflammation in BAT, and reduces circulating NEFA and adiponectin levels. As a consequence, cardiac function is reduced, scar formation enhanced, and remote myocardium shows elevated mechanical stress and oxygen consumption ...
Heba Zabri, Alisa Ucar, Luzhou Wang, Simone Gorressen, Richard Kretschmer, Daniel Gorski, Tobias Lautwein, Mirela Balan, Stefan Lehr, Andre Heinen, Axel Gödecke, Jens W. Fischer, Katharina Bottermann   +12 more
wiley   +1 more source