Results 211 to 220 of about 64,618 (285)
Selective Delivery of Anticancer Natural G-Quadruplex Ligands by the AT11 Aptamer for Gastric Cancer Treatment. [PDF]
Platella C +8 more
europepmc +1 more source
Müller Glial Kir4.1 Channel Dysfunction in APOE4‐KI Model of Alzheimer's Disease
APOE4 impairs Müller cell health by reducing Kir4.1 expression and buffering. APOE4 causes mitochondrial dysfunction with decreased ΔΨm and increased ROS. MitoQ restores Kir4.1 expression and reduces ROS in APOE4‐transfected cells. ABSTRACT Alzheimer's disease (AD), particularly late‐onset AD (LOAD), affects millions worldwide, with the apolipoprotein ...
Surabhi D. Abhyankar +8 more
wiley +1 more source
GSDME-N-induced mitochondrial neurotoxicity in early neurodegeneration was suppressed by nicotine via enhancing autophagic flux. [PDF]
Zhao J +5 more
europepmc +1 more source
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard +2 more
wiley +1 more source
Red and near-infrared light treatment can change the intensity of biophoton emissions in cell culture. [PDF]
Hoh Kam J +4 more
europepmc +1 more source
First use of a natural swine model with lipid metabolism to directly link lipid differences to a quantifiable intestinal villus height phenotype. Identified the phospholipid‐derived oleoylethanolamide, rather than canonical fatty acids, as the endogenous primary ligand that activates peroxisome proliferator‐activated receptors α (PPARα) to enlarge ...
Qianqian Wang +9 more
wiley +1 more source
Inhibition of pro-apoptotic UPR pathways PERK/CHOP and IRE1/JNK protects differentiated SH-SY5Y cells against rotenone-induced toxicity. [PDF]
Siwecka N +5 more
europepmc +1 more source
Wild‐Derived House Mice (Mus musculus) Are Able to Cope With a Constant Light Environment
ABSTRACT Exposure to altered nighttime lighting conditions has become common in today's modern world. Light at night disrupts circadian processes that govern feeding patterns, sleep/wake cycles, and metabolic homoeostasis, increasing the risk of developing pathologies associated with cardiometabolic disease. Yet, the underlying mechanism(s) responsible
Kevin Pham +4 more
wiley +1 more source

