Results 91 to 100 of about 30,307 (306)

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Numerical Analysis of Performance, Rotor Temperature Distributions, and Rotor Thermal Deformation of an R134a Screw Compressor

, 2012
A numerical analysis is performed to systematically calculate the performance, rotor temperature distributions, and rotor thermal deformation of an R134a screw compressor. The analysis procedure includes three major steps.
Hsieh, Wenhsin, Huang, Chishun, Hsieh, Shenghung, Huang, Yuhua   +3 more
core  

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Integration of CFD tools in aerodynamic design of contra-rotating propellers blades [PDF]

, 2011
A strategy for Contra-Rotating Open Rotors blades design is presented. It is based on several analytical or CFD tools with increasing levels of accuracy. A preliminary design is made with a lifting-line code. These first geometries are then validated and
Béchet, Sylvain, Negulescu, Camil A., Chapin, Vincent, Simon, Frank   +3 more
core  

Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors

, 2017
The sensitivity of structurally similar BODIPY-based molecular rotors to viscosity, temperature and solvent polarity was investigated.
Ismael López-Duarte, Nicolas Duchemin, Vu, Thanh-Truc, Volkova, Yulia A., Yulia A. Volkova, Peña Cabrera, Eduardo, Ramírez-Ornelas, Diana E., Duchemin, Nicolas, Ekaterina M. Budynina, López Duarte, Ismael, Kuimova, Marina K., Budynina, Ekaterina M., Diana E. Ramírez-Ornelas, Marina K. Kuimova, Vyšniauskas, Aurimas, Aurimas Vyšniauskas, Eduardo Peña Cabrera, Thanh-Truc Vu, Wu, Yilei, Yilei Wu   +19 more
core   +1 more source

Concurrently Achieving 4.6 W/M2 and 120,000 Cyclability Enabled by Extendable Swing Arms in Rotational Triboelectric Nanogenerator

Advanced Science, EarlyView.
A rotational energy harvesting device that successfully reconciles high power density with mechanical durability through a hybrid sliding‐and‐bouncing kinematic mechanism is reported. The success reported in our paper includes addressing a dilemma where enhanced electrical output comes at the cost of increased friction and wear, limiting the practical ...
Yihong Lin, Jiaming Zhou, In‐Yong Suh, Eunjong Kim, Kin Chiu Yip, Dae‐jin Kim, Jang‐Mook Jeong, Young‐Jun Kim, Jinyoung Jeon, Ju‐Hyuck Lee, Yoon‐Hwae Hwang, Sang‐Woo Kim, Dong‐Myeong Shin   +12 more
wiley   +1 more source

Self‐Powered Bearing Sensing and Real‐Time Fault Diagnosis Enabled by Non‐Invasive Triboelectric Sensors and Edge AI Acceleration

Advanced Science, EarlyView.
This study achieves the synergistic integration of self‐powered sensing and edge AI acceleration to establish a real‐time fault diagnosis system. The proposed TENG‐based self‐powered bearing sensor (NSE‐TBS) and FPGA‐accelerated edge AI framework fundamentally break through the inherent limitations of conventional monitoring systems, including complex ...
Kehui Zhu, Zhongheng Liu, Xinming Li, Jinrui Zhang, Meng Li, Yiming Guo, Lihua Han, Yanxue Wang   +7 more
wiley   +1 more source

Different options for multi-rotor wind turbine grid connection

The Journal of Engineering, 2019
Here, different options for integration of the multi-rotor wind turbine (MRWT) concept are investigated. The intra-turbine collection network of the MRWT can be designed in either AC or DC. The reliability and costs associated with each connection option
Kamyab Givaki
doaj   +1 more source

Development of a test-rig for exploring optimal conditions of small unmanned aerial vehicle co-axial rotor systems

, 2010
Due to the recent increase in development and use of co-axial rotor system at the scale of small UAVs a greater understanding of the performance variables that affect the co-axial propulsion system at low Reynolds number operation has become increasingly
Brazinskas, Mantas, Prior, Stephen D., Bell, Jonathon, Erbil, Mehmet Ali, Karamanoglu, Mehmet   +4 more
core