Results 121 to 130 of about 117,411 (298)

Generating formally certified bounds on values and round-off errors [PDF]

, 2004
International audienceWe present a new tool that generates bounds on the values and the round-off errors of programs using floating point operations. The tool is based on forward error analysis and interval arithmetic.
Melquiond, Guillaume, Daumas, Marc
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Deadly Round-Off Error: Failure of the Patriot System in Dhahran 1991

On February 25, 1991, a Patriot missile defence system operating in Dhahran, Saudi Arabia, failed to engage an incoming Scud missile. The missile struck U.S. Army barracks, killing 28 soldiers and injuring 98.
Sağlam, Timur
core   +1 more source

The root and Bell’s disk iteration methods are of the same error propagation characteristics in the simultaneous determination of the zeros of a polynomial, Part II: Round-off error analysis by use of interval arithmetic

, 2011
In Part I (Ikhile, 2008) [4], it was established that the root and Bell’s disk/point iteration methods with or without correction term are of the same asymptotic error propagation characteristics in the simultaneous determination of the zeros of a ...
Ikhile, M.N.O., M.N.O. Ikhile
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The effect of round-off error on long memory processes

We study how the round-off (or discretization) error changes the statistical properties of a Gaussian long memory process. We show that the autocovariance and the spectral density of the discretized process are asymptotically rescaled by a factor smaller
Gabriele La Spada, Fabrizio Lillo
core  

Distribution of round-off errors for running averages [PDF]

Pacific Journal of Mathematics, 1953
Greenwood, R. E., Gleason, A. M.
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Cholla-MHD: An Exascale-capable Magnetohydrodynamic Extension to the Cholla Astrophysical Simulation Code

The Astrophysical Journal
We present an extension of the massively parallel, GPU native, astrophysical hydrodynamics code Cholla to magnetohydrodynamics (MHD). Cholla solves the ideal MHD equations in their Eulerian form on a static Cartesian mesh utilizing the Van
Robert V. Caddy, Evan E. Schneider
doaj   +1 more source