Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Adaptive link-weight routing protocol using cross-layer communication for MANET [PDF]
, 2007 Routing efficiency is one of the challenges offered by Mobile Ad-hoc Networks (MANETs). This paper proposes a novel routing technique called Adaptive Link-Weight (ALW) routing protocol.
Al-Khwildi, AN +3 more
core +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
A compreensão dos movimentos dos leitores em documentos www
InfoDesign: Brazilian Journal of Information Design, 2004 Este estudo objetiva identificar os movimentos dos leitores no espaço virtual e, para tanto, está estruturado como sendo uma viagem através do ambiente da Rede Mundial de computadores (www).
María González de Cossío
doaj
IMPLEMENTASI ALGORITMA DIJKSTRA SEBAGAI SOLUSI EFEKTIF PEMBUATAN SISTEM BANTUAN BENCANA REAL TIME
Jurnal Ilmiah Teknik Industri, 2013 Research on communications technologies that support by Dijkstra algorithm, as a determinant of the distribution are more effective for the volunteer. The system also equipped by the data inventory and needs of each refugee, so there is no buildup and ...
Siti Nandiroh +2 more
doaj +1 more source
Intercompartmental communication in senescence
FEBS Open Bio, EarlyView.Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz +3 more
wiley +1 more source
Prospects of introduction of innovative technology overhead passenger traffic on the basis of the passenger ropeways for the modernization of the public transport system of the Bryansk city [PDF]
Научно-технический вестник Брянского государственного университета, 2017 In relation to the current situation in the field of public transport in the Bryansk city was shown the main problems in the implementation of innovative technology for the aerial passenger transport on the basis of suspended passenger ropeways (Cable ...
Lagerev A.V., Lagerev I.A.
doaj
Naloxone Administration Route in Opioid Overdose: A Review of Vermont EMS Data [PDF]
, 2017 Objective: Emergency Medical System (EMS) personnel administer the direct opioid antagonist naloxone in cases of opioid overdose via intramuscular (IM), intravenous (IV), subcutaneous (SQ), intraosseous (IO), or intranasal (IN) routes. Some early studies
LaMonda, Chris, MPH +4 more
core +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Conceptualising Heritage Routes for Tourism: The Miracle of the Roses
International Journal of Religious Tourism and PilgrimageIn this article, a preliminary exploratory study is undertaken to cover a lesser researched topic in the tourism literature concerning the conceptualisation of heritage-based routes.
Isilda Leitão, Carlos Fernandes
doaj +1 more source