Results 71 to 80 of about 3,264,220 (298)

What’s in it for me? Incentive-compatible route coordination of crowdsourced resources [PDF]

open access: yes, 2016
With the recent trend in crowdsourcing, i.e., using the power of crowds to assist in satisfying demand, the pool of resources suitable for GeoPresence-capable systems has expanded to include already roaming devices, such as mobile phones, and moving ...
Bassem, Christine, Bestavros, Azer
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Arricchimento semantico del turismo alpino

open access: yesGEOmedia, 2010
Semantic enrichment of alpine tourism Ontological enrichment from semantic Web finds its own achievement in tourism information, mostly those related to alpine world.
Eliseo Clementini, Francesco Bartoli
doaj   +2 more sources

Routing for manufacturability [PDF]

open access: yesProceedings of the 31st annual conference on Design automation conference - DAC '94, 1994
The impact of spot defects on the susceptibility for electrical failure of a net is analyzed. Based on this analysis, a general routing cost function is presented, in which the manufacturability of a net is taken into account in conjunction with the traditional routing objectives.
Xue, H., Huijbregts, E.P., Jess, J.A.G.
openaire   +2 more sources

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

open access: yesFEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber   +7 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

A VCG-Based Multiepitope Chlamydia Vaccine Incorporating the Cholera Toxin A1 Subunit (MECA) Confers Protective Immunity Against Transcervical Challenge

open access: yesBiomedicines
Background/Objectives: We generated a novel recombinant Vibrio cholerae ghost (rVCG)-based subunit vaccine incorporating the A1 subunit of cholera toxin (CTA1) and a multiepitope Chlamydia trachomatis (CT) antigen (MECA) derived from five chlamydial ...
Fnu Medhavi   +5 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

AUGMENTED REALITY OF STREET ART ROUTE FOR TOURISM, THAILAND [PDF]

open access: yesGeo Journal of Tourism and Geosites
Augmented Reality (AR) has been identified as a powerful tool for enhacing the tourism experience. It enables the visualization of historical attractions, cultural narratives, and educational content, and fostering deeper engagement with destinations ...
Numtip TRAKULMAYKEE*   +3 more
doaj   +1 more source

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