Results 91 to 100 of about 3,264,220 (298)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Spectrum Sharing Scheme Between Cellular Users and Ad-hoc Device-to-Device Users

open access: yes, 2013
In an attempt to utilize spectrum resources more efficiently, protocols sharing licensed spectrum with unlicensed users are receiving increased attention. From the perspective of cellular networks, spectrum underutilization makes spatial reuse a feasible
Aazhang, Behnaam   +2 more
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

A compreensão dos movimentos dos leitores em documentos www

open access: yesInfoDesign: Brazilian Journal of Information Design, 2004
Este estudo objetiva identificar os movimentos dos leitores no espaço virtual e, para tanto, está estruturado como sendo uma viagem através do ambiente da Rede Mundial de computadores (www).
María González de Cossío
doaj  

IMPLEMENTASI ALGORITMA DIJKSTRA SEBAGAI SOLUSI EFEKTIF PEMBUATAN SISTEM BANTUAN BENCANA REAL TIME

open access: yesJurnal Ilmiah Teknik Industri, 2013
Research on communications technologies that support by Dijkstra algorithm, as a determinant of the distribution are more effective for the volunteer. The system also equipped by the data inventory and needs of each refugee, so there is no buildup and ...
Siti Nandiroh   +2 more
doaj   +1 more source

Adaptive link-weight routing protocol using cross-layer communication for MANET [PDF]

open access: yes, 2007
Routing efficiency is one of the challenges offered by Mobile Ad-hoc Networks (MANETs). This paper proposes a novel routing technique called Adaptive Link-Weight (ALW) routing protocol.
Al-Khwildi, AN   +3 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Prospects of introduction of innovative technology overhead passenger traffic on the basis of the passenger ropeways for the modernization of the public transport system of the Bryansk city [PDF]

open access: yesНаучно-технический вестник Брянского государственного университета, 2017
In relation to the current situation in the field of public transport in the Bryansk city was shown the main problems in the implementation of innovative technology for the aerial passenger transport on the basis of suspended passenger ropeways (Cable ...
Lagerev A.V., Lagerev I.A.
doaj  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Conceptualising Heritage Routes for Tourism: The Miracle of the Roses

open access: yesInternational Journal of Religious Tourism and Pilgrimage
In this article, a preliminary exploratory study is undertaken to cover a lesser researched topic in the tourism literature concerning the conceptualisation of heritage-based routes.
Isilda Leitão, Carlos Fernandes
doaj   +1 more source

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