Results 81 to 90 of about 3,803,647 (352)
Landscape of BRAF transcript variants in human cancer
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda+5 more
wiley +1 more source
We draw on evidence scattered across thick descriptions of organizations to outline an alternative model of routine. Instead of defining routine as a process of compliance with prescribed rules and procedures we define it as a process of deviation from ...
Chia, Robert+2 more
core
TRPM8 levels determine tumor vulnerability to channel agonists
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo+18 more
wiley +1 more source
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton+17 more
wiley +1 more source
The Kaprekar Routine and Other Digit Games for Undergraduate Exploration [PDF]
The Kaprekar Routine is a famous mathematical procedure involving the digits of a positive integer. This paper offers natural generalizations of the routine, states and proves related results, and presents many open problems that are suitable for ...
Peterson, K., Pulapaka, H.
core +1 more source
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed+8 more
wiley +1 more source
"Violência urbana", segurança pública e favelas: o caso do Rio de Janeiro atual
O artigo propõe uma descrição empírica da produção da linguagem da violência urbana (entendida como uma prática organizada, uma gramática) e das respectivas implicações sobre a ordem pública. Dois conjuntos de questões são abordados e relacionados: a) as
Luiz Antonio Machado da Silva
doaj +1 more source
Collaborative learning through art games. Reflecting on corporate life with ‘Every Day the Same Dream’ [PDF]
A consistent thread of literature has been dedicated to video games as a learning medium. Recently, attention has been increasingly given to games as opportunities for philosophical or ideological reflection on life.
Alina Petra Marinescu-Nenciu
doaj
Introduction: Spontaneous bacterial peritonitis (SBP) as a monomicrobial infection of ascites fluid is one of the most important causes of morbidity and mortality in cirrhotic patients. This study was aimed to determine the diagnostic accuracy of ascites
Hamed Aminiahidashti+6 more
doaj +1 more source
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho+11 more
wiley +1 more source