Results 111 to 120 of about 565,488 (365)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

LBR: Load balancing routing algorithm for wireless sensor networks

open access: yes, 2010
Homogeneous wireless sensor networks (WSNs) are organized using identical sensor nodes, but the nature of WSNs operations results in an imbalanced workload on gateway sensor nodes which may lead to a hot-spot or routing hole problem.
Dixon, M.W., Daabaj, K., Koziniec, T.
core  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Let the Tree Bloom: Scalable Opportunistic Routing with ORPL [PDF]

open access: yes, 2013
Routing in battery-operated wireless networks is challenging, posing a tradeoff between energy and latency. Previous work has shown that opportunistic routing can achieve low-latency data collection in duty-cycled networks.
Voigt, Thiemo,   +7 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

The Fleet Size and Mix vehicle Routing Problem with backhauls: Formulation and Set partitioning-based heuristics [PDF]

open access: yes, 2013
In this paper we present a new variant of the classical Vehicle Routing Problem – the Fleet Size and Mix Vehicle Routing Problem with Backhauls (FSMVRPB). An ILP formulation of the FSMVRPB is presented.
Hajarat, Mutaz   +2 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

A MinMax Routing Algorithm for Long Life Route Selection in MANETs

open access: yesInternational Journal of Information and Communication Technology Research, 2015
In this paper, the stable or long life route selection problem in Mobile Ad-hoc Wireless Networks (MANETs) is addressed. The objective is to develop an on demand routing scheme to find a long life route between a given source and destination assuming ...
Abdorasoul Ghasemi, Mahmood Mollaei
doaj  

Fuzzy Logic Aided Dynamic Source Routing in Cross-Layer Operation Assisted Ad Hoc Networks [PDF]

open access: yes, 2010
The classic Dynamic Source Routing (DSR) protocol opts for the route requiring the lowest number of hops for transmitting data from the source to the destination.
Soon Xin Ng   +5 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

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