Results 101 to 110 of about 312,387 (300)

High‐Resolution National‐Scale Water Modeling Is Enhanced by Multiscale Differentiable Physics‐Informed Machine Learning

Water Resources Research
The National Water Model (NWM) is a key tool for flood forecasting, planning, and water management. Key challenges facing the NWM include calibration and parameter regionalization when confronted with big data.
Yalan Song, Tadd Bindas, Chaopeng Shen, Haoyu Ji, Wouter J. M. Knoben, Leo Lonzarich, Martyn P. Clark, Jiangtao Liu, Katie vanWerkhoven, Sam Lamont, Matthew Denno, Ming Pan, Yuan Yang, Jeremy Rapp, Mukesh Kumar, Farshid Rahmani, Cyril Thébault, Richard Adkins, James Halgren, Trupesh Patel, Arpita Patel, Kamlesh Arun Sawadekar, Kathryn Lawson   +22 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

A savings based method for real-life vehicle routing problems [PDF]

This paper describes a Savings Based algorithm for the Extended Vehicle Routing Problem. This algorithm is compared with a Sequential Insertion algorithm on real-life data.
Wagelmans, A.P.M., Poot, A., Kant, G.
core  

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

A deterministic tabu search algorithm for the capacitated arc routing problem [PDF]

, 2008
The capacitated arc routing problem (CARP) is a difficult optimisation problem in vehicle routing with applications where a service must be provided by a set of vehicles on specified roads.
Eglese, R W, Brandao, J, José Brandão, Richard Eglese   +3 more
core   +2 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Interdomain routing and games [PDF]

We present a game-theoretic model that captures many of the intricacies of \emph{interdomain routing} in today's Internet. In this model, the strategic agents are source nodes located on a network, who aim to send traffic to a unique destination node ...
Zohar, Aviv, Levin, Hagay, Schapira, Michael   +2 more
core  

Pervasive intelligent routing in content centric delay tolerant networks [PDF]

, 2011
This paper introduces a Swarm-Intelligence based Routing protocol (SIR) that aims to efficiently route information in content centric Delay Tolerant Networks (CCDTN) also dubbed pocket switched networks.
Ramiro, Victor, Anh Dung Nguyen, Sénac, Patrick, Patrick Senac, Michel Diaz, Victor Ramiro, Diaz, Michel, Nguyen, Anh-Dung   +7 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source