Results 101 to 110 of about 1,696,939 (336)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Improving River Routing Using a Differentiable Muskingum‐Cunge Model and Physics‐Informed Machine Learning

Water Resources Research
Recently, rainfall‐runoff simulations in small headwater basins have been improved by methodological advances such as deep neural networks (NNs) and hybrid physics‐NN models—particularly, a genre called differentiable modeling that intermingles NNs with ...
Tadd Bindas, Wen‐Ping Tsai, Jiangtao Liu, Farshid Rahmani, Dapeng Feng, Yuchen Bian, Kathryn Lawson, Chaopeng Shen   +7 more
doaj   +1 more source

EFFICIENT ROUTING PROTOCOL ALGORITHM FOR WIRELESS SENSOR NETWORKS

Iraqi Journal for Computers and Informatics, 2018
Recently, different applications of wireless sensor networks (WSNs) in the industry fields using different data transfer protocols has been developed. As the energy of sensor nodes is limited, prolonging network lifetime in WSNs considered a significant ...
Sayed Seno, Doaa Abd Ali, Mohammed Mohammed   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

High‐Resolution National‐Scale Water Modeling Is Enhanced by Multiscale Differentiable Physics‐Informed Machine Learning

Water Resources Research
The National Water Model (NWM) is a key tool for flood forecasting, planning, and water management. Key challenges facing the NWM include calibration and parameter regionalization when confronted with big data.
Yalan Song, Tadd Bindas, Chaopeng Shen, Haoyu Ji, Wouter J. M. Knoben, Leo Lonzarich, Martyn P. Clark, Jiangtao Liu, Katie vanWerkhoven, Sam Lamont, Matthew Denno, Ming Pan, Yuan Yang, Jeremy Rapp, Mukesh Kumar, Farshid Rahmani, Cyril Thébault, Richard Adkins, James Halgren, Trupesh Patel, Arpita Patel, Kamlesh Arun Sawadekar, Kathryn Lawson   +22 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Interdomain routing and games [PDF]

We present a game-theoretic model that captures many of the intricacies of \emph{interdomain routing} in today's Internet. In this model, the strategic agents are source nodes located on a network, who aim to send traffic to a unique destination node ...
Zohar, Aviv, Levin, Hagay, Schapira, Michael   +2 more
core  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source