Results 91 to 100 of about 565,488 (365)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Proposal of Load Aware Routing for OSPF Routing Protocol
Communications, 2013 This paper deals with route cost assignment using one of the most commonly used routing protocols - Open Shortest Path First (OSPF). The limitation of this protocol is that the algorithm does not take actual link load into consideration.
Tomas Macha, Radko Krkos, Vit Novotny
doaj +1 more source
Cognitive routing for wireless ad hoc networks [PDF]
, 2011 This thesis examines the design of cognitive routing to improve wireless ad hoc network performance in terms of throughput and delay, as well as reducing the impact of relaying on the network, without deteriorating end-to-end capacity.
Han, Bo
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Water Resources ResearchRecently, rainfall‐runoff simulations in small headwater basins have been improved by methodological advances such as deep neural networks (NNs) and hybrid physics‐NN models—particularly, a genre called differentiable modeling that intermingles NNs with ...
Tadd Bindas +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Water Resources ResearchThe National Water Model (NWM) is a key tool for flood forecasting, planning, and water management. Key challenges facing the NWM include calibration and parameter regionalization when confronted with big data.
Yalan Song +22 more
doaj +1 more source
Performance analysis of MANET routing protocols in the presence of self-similar traffic [PDF]
, 2006 A number of measurement studies have convincingly demonstrated that network traffic can exhibit a noticeable self-similar nature, which has a considerable impact on queuing performance.
Ould-Khaoua, M. +3 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source