Results 71 to 80 of about 312,387 (300)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
IPP Routing Architecture [PDF]
, 1994 This paper describes the structure of the IPP routing architecture. IPP is an evolution of the TCP-IP protocol. The main advantage of IPP is the variable length addressing scheme.
Bolla, Damiano, Damiano Bolla
core
IEEE Access, 2022 Nowadays, advanced communication technologies are being utilized to develop intelligent transportation management and driving assistance. Through the ability to exchange traffic and infotainment information between road infrastructure and vehicles ...
Nehad Hameed Hussein +4 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Multi-Agent Reinforcement Learning Framework in SDN-IoT for Transient Load Detection and Prevention
Technologies, 2021 The fast emergence of IoT devices and its accompanying big and complex data has necessitated a shift from the traditional networking architecture to software-defined networks (SDNs) in recent times. Routing optimization and DDoS protection in the network
Delali Kwasi Dake +3 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Routing with Renewable Energy Management in Wireless Sensor Networks
Sensors, 2021 In wireless sensor networks (WSNs), power consumption is an important aspect when designing routing protocols. When compared to other components of a sensor node, the power required by radio transmitters is responsible for most of the consumption.
João Junior +4 more
doaj +1 more source