Results 111 to 120 of about 13,762 (186)

Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism

The FEBS Journal, EarlyView.
AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney, James Griffin, Nouf Khan, Balnur Ibrash, Matthew J. O'Connor, Tomas Venit, Elizabeth Mayela Ambrosio, Spiros A. Pergantis, Elke Ober, Piergiorgio Percipalle, Kirsten C. Sadler   +10 more
wiley   +1 more source

TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics

The FEBS Journal, EarlyView.
This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga, Zsolt Ráduly, Beáta Boros‐Oláh, Éva Nagy, Zsolt Karányi, László Halász, Bálint László Bálint, György Vámosi, Emese Tóth, Péter Bai, Serena Santangelo, Patrizia Bossolasco, Antonia Ratti, Vincent Géli, Yves Pommier, Lóránt Székvölgyi   +15 more
wiley   +1 more source

ROX index: An important predictor of high-flow nasal cannula and non-invasive ventilation failure. [PDF]

Lung India, 2023
Chakrabarti A, Kundu R, Chowdhury SR.
europepmc   +1 more source

THE ROLE OF RESPIRATORY INDEX, ROX INDEX, AND MODIFIED EARLY WARNING SCORE IN PREDICTING EXTUBATION FAILURE [PDF]

Chest, 2021
AMNAH ALOLAIWAT, RAMANDEEP KAUR, DAVID VINES   +2 more
openaire   +1 more source

Tankyrase‐2 regulates adipocyte differentiation through AMPK/mTOR signaling

The FEBS Journal, EarlyView.
Tankyrase 2 (TNKS2), a PARP family member, underpins adipocyte differentiation. TNKS2 controls LKB1 protein level, and consequently, the activity of the mTOR/AMPK system and adipocyte differentiation through a layered process. Pharmacological inhibition of TNKS2 leaves other PARPs and DNA repair active and therefore represents a novel target in ...
Boglarka Rauch, Gyula Ujlaki, Szilard Poliska, Nakayi Murahwa, Patrik Kovacs, Aladar Pettko‐Szandtner, Karen Uray, Peter Bai   +7 more
wiley   +1 more source

Sclerostin regulates bone morphogenetic protein (BMP) bioavailability through interactions with BMP complexes and fibrillin microfibrils

The FEBS Journal, EarlyView.
Sclerostin (SOST) is a multifunctional extracellular modulator of BMP and Wnt signaling. SOST binds with high affinity to fibrillin‐1 and fibrillin‐2, localizing it to fibrillin microfibrils and regulating its extracellular bioavailability. Fibrillin‐bound SOST cannot engage BMP‐7 prodomain (PD) complexes, revealing a competitive mechanism that ...
Annkatrin Correns, Fady Marcous, Steffen Lütke, Matthias Mörgelin, Philipp Barnowski, Ariane G. Furlan, Nathalie H. Schröder, Bodo Levkau, Sarah Riek, Martin Mollenhauer, Manuel Koch, Gerhard Sengle   +11 more
wiley   +1 more source

Nature and timing of dysregulation associated with pseudoalbinism in California Halibut, Paralichthys californicus

Journal of Fish Biology, EarlyView.
Abstract Pseudoalbinism in flatfishes, the absence of melanophores or melanin over most of the ocular side of the body, is often observed in hatcheries. The prevalence of pseudoalbinism can be very high, sometimes exceeding 90% of individuals in California Halibut, Paralichthys californicus.
Lee A. Fuiman, Cynthia K. Faulk, Ruairi MacNamara   +2 more
wiley   +1 more source

Development of a Multiplex Quantitative PCR Assay for Simultaneous Detection of Multiple Vibrio Species in Aquaculture Samples

Journal of Fish Diseases, EarlyView.
ABSTRACT Aquaculture associated Vibrio species are important bacterial pathogens causing significant economic losses in aquaculture and zoonotic infections in humans. Rapid and accurate detection of Vibrio species is therefore essential for diagnosis, surveillance and control.
İnci Başak Müştak, Hamit Kaan Müştak, Seyyide Sarıçam İnce, Doğukan Uğun, Görkem Cengiz, Gültekin Ünal, Ebru Torun, Muammer Göncüoğlu   +7 more
wiley   +1 more source

Predictive Accuracy of the ROX Index for Re-Intubation in Mechanically Ventilated Patients With COVID-19. [PDF]

Respir Care, 2023
Okazaki Y, Nishikimi M, Ishii J, Ota K, Ohshimo S, Shime N.   +5 more
europepmc   +1 more source

ROX vector to complement ROX index during nasal high flow therapy of hypoxemic patients

Journal of Critical Care, 2020
openaire   +2 more sources