Results 131 to 140 of about 13,762 (186)

Mitochondrial capacities and quality control following short‐ and long‐term weight restoration after simulated anorexia nervosa

Experimental Physiology, EarlyView.
Abstract Anorexia nervosa (AN) is a psychiatric disorder characterized by prolonged caloric restriction and skeletal muscle atrophy. Mitochondrial health is a key mediator of muscle function, yet the role of mitochondria during AN and following weight regain has not been investigated. The objective of this study was to evaluate mitochondrial capacities
Megan E. Rosa‐Caldwell, Toby L. Chambers, Lauren Breithaupt, Ruqaiza Muhyudin, Patience Salvalina Okoto, Sadie R. Thompson, Emily E. Rothacker, Claire Greenhill, Katie A. Wood, Kevin A. Murach, Sarah H. White‐Springer, Ursula B. Kaiser, Seward B. Rutkove   +12 more
wiley   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

microRNA‐145‐5p regulates P‐glycoprotein and breast cancer resistance protein in primary human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend Drug transporters P‐glycoprotein (P‐gp) and breast cancer resistance protein (BCRP) at the blood–brain barrier (BBB) protect the rapidly developing fetal brain. We investigated the role of microRNA‐145‐5p (miR‐145‐5p) microRNA (miRNA) in regulating these key transporters in primary human fetal brain endothelial cells in vitro. We
Phetcharawan Lye, Enrrico Bloise, Nikola Ivanovski, Lubna Nadeem, Christopher Casciaro, Stephen G. Matthews   +5 more
wiley   +1 more source

Ascending infection of Gardnerella spp. and compartmentalized inflammatory response in fetal–maternal interface organ‐on‐chip model

The Journal of Physiology, EarlyView.
Abstract figure legend The fetal–maternal interface organ‐on‐chip was used to investigate the ascending infection of Gardnerella spp. across the decidua (DEC), chorion trophoblast (CTC), amnion mesenchymal (AMC) and amnion epithelial (AEC) compartments over 48 h.
Mariana de Castro Silva, Jeniffer Sena Baptista Ferreira, Rafael Gomes Barnabé, Maria Eduarda Tesini Rocha, Laura Emi Yonezawa de Souza, Bruna Ribeiro de Andrade Ramos, Ramkumar Menon, Márcia Guimarães da Silva   +7 more
wiley   +1 more source

The Wild Soybean C3HC4‐Type RING Zinc‐Finger Protein ZFP4 Enhances Resistance to Soybean Mosaic Virus

Plant, Cell &Environment, Volume 49, Issue 12, Page 10149-10162, December 2026.
ABSTRACT Soybean [Glycine max (L.) Merr.] is a globally important source of protein and edible oil, but is severely threatened by soybean mosaic virus (SMV). Wild soybean [Glycine soja Sieb. & Zucc.], the wild ancestor of cultivated soybean, exhibits high genetic diversity and strong resistance to pathogens.
Yixiang Pu, Yingying Song, Rufei Yang, Changyun Yang, Zhongyi Yang, Shupeng Dong, Wei Zhao, Jiao Wang, Zhiping Huang, Wei Li, Yingdong Bi, Yongcai Lai, Hengyou Zhang, Hui Wang, Deyue Yu, Qian Wu, Hao Cheng   +16 more
wiley   +1 more source

Derivation and Exploratory Evaluation of the Respiratory Rate-Oxygenation (ROX) Index as a Predictor of High-Flow Nasal Cannula Outcomes in Patients With COVID-19 Pneumonia. [PDF]

Cureus
Chandra R, Ankita, Kumar H, Kumar S, Kaushal A, Jain A, Sinha N.   +6 more
europepmc   +1 more source

Villoglandular Adenocarcinoma of the Cervix With Ovarian Metastasis Mimicking a Borderline Ovarian Tumor: A Rare Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT This case reports rare cervical villoglandular adenocarcinoma metastasizing to the ovary with a deceptive borderline‐like morphology. Diagnosis relied on matching immunohistochemistry and HPV16 DNA detection in both sites. The patient underwent surgery and chemoradiotherapy, remaining recurrence‐free.
Ni Ma, Xiang Xu, Zhengpeng Zhu, Tianfang Xin, Yaxiong Huang   +4 more
wiley   +1 more source

The Use of the "Respiratory Rate Oxygenation (ROX) Index" in the Assessment of Respiratory Support and Observation of Its Outcome in COVID-19 Patients With Acute Respiratory Failure. [PDF]

Cureus, 2023
Bhuiyan AT, Hossain M, Khan MJ, Hossain B, Sultana SA, Sharmin F, Akhtaruzzaman A.   +6 more
europepmc   +1 more source

Copy Number Variation‐Based Molecular Sexing of Ixodes scapularis and Rhipicephalus microplus Immature Stages Using qPCR and ddPCR Approaches

Ecology and Evolution, Volume 16, Issue 11, November 2026.
We developed and validated a copy number variation (CNV)‐based molecular method to accurately determine the sex of immature ticks, Ixodes scapularis and Rhipicephalus microplus, which lack morphological sexual dimorphism. Using qPCR and ddPCR assays targeting female‐enriched genes, sex was reliably identified from DNA extracted non‐destructively from a
Arvind Sharma, Benjamin Faustino, Isaac Hinne, Jakub Wudarski, Saransh Beniwal, Nurul Hamidi, Kyla Ercit, Sanjay Basu, Malimba Lisulo, Mattia Poletto, Kelly J. Matzen, Monika Gulia‐Nuss   +11 more
wiley   +1 more source

Betaine Attenuates Cuprizone‐Induced Cortical Demyelination: The Role of the WNT4/mTOR Signalling Pathway in Regulating Astrogliosis and Synaptic Integrity

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Betaine helps to restore the dysfunctional communication between oxidative stress and inflammation, and it also improves demyelination in cuprizone‐induced demyelinating disease within the cerebral cortex. ABSTRACT Cortical grey matter pathology manifests early demyelinating diseases and is a primary driver of permanent neurological impairment.
Yara M. Said, Heba‐Tallah Abd Elrahim Abd Elkader, Gihad Jamal Bekheet, Sherine Abdel Salam, Amina E. Essawy   +4 more
wiley   +1 more source