Results 121 to 130 of about 59,227 (260)

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

AQbD-driven development of a green RP-HPLC method for nirogacestat with LC-MS structural elucidation. [PDF]

BMC Chem
Sabi J, Kannaiah KP, Chanduluru HK, Nakka S, Elagamy SH, Obaydo RH.   +5 more
europepmc   +1 more source

Synergistic and Antagonistic Effects of Chemical Pollutants and Parasitic Fungi on Cyanobacterial Metabolism

Environmental Toxicology, EarlyView.
ABSTRACT Freshwater ecosystems are increasingly impacted by anthropogenic pollutants, including the widely used herbicide metolachlor (MET) and cigarette butt (CB) litter. Parasites represent an additional biotic stressor that can modulate pollutant effects on their hosts.
Erika Berenice Martínez‐Ruiz, Jutta Fastner, Stephanie Spahr, Justyna Wolinska   +3 more
wiley   +1 more source

A novel green QbD-optimized RP-HPLC bioanalytical method for the simultaneous determination of doxorubicin and rifampicin in human plasma. [PDF]

BMC Chem
Magdy G, Ebrahim S, Belal F, Abdel-Megied AM.   +3 more
europepmc   +1 more source

Protective Effects of Bee Venom (Apis mellifera) Against Cadmium‐Induced Hepatorenal Toxicity, Oxidative Stress, and Anxiety‐Like Behavior in Rats

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a persistent environmental heavy metal and a major public health concern because it persists in the body for long periods and gradually accumulates in vital organs, particularly the liver, kidneys, and brain. Chronic Cd exposure promotes the excessive production of reactive oxygen species (ROS), which ultimately leads to ...
Soumaya Ghodbane, Chedli Ellijimi, Rym Elfessi, Ranya Hezzi, Khemaies Ben Rhouma, Hafedh Abdelmelek, Najet Srairi‐Abid, Mohsen Sakly, Riadh Marrouchi   +8 more
wiley   +1 more source

Eco-friendly RP-HPLC determination of bambuterol hydrochloride and montelukast sodium in tablet dosage with dissolution analysis. [PDF]

Sci Rep
Ibrahim M, Ramadan NK, Ibrahim MM, Boltia SA.   +3 more
europepmc   +1 more source

Nutritional composition of pollen stores in managed bees across European agro‐ecosystems reveals species‐specific differences but limited pesticide effects

Ecological Entomology, EarlyView.
In the pollen stores of three bee species deployed across 128 European sites, bumble bees harboured lower lipid content and higher protein‐to‐lipid ratios than honey bees and mason bees. Toxicity‐weighted pesticide risk did not alter protein‐to‐lipid ratios, but higher risk was associated with reduced protein and lipid content in the pollen stores of ...
Antoine Gekière, Clément Tourbez, Maryse Vanderplanck, Tomasz Kiljanek, Guillaume Ghisbain, Elif Kardas, Irene Bottero, Marie‐Pierre Chauzat, Elena Cini, Francesca Corvucci, Joachim R. de Miranda, Gennaro Di Prisco, Christophe Dominik, Francesca V. Grillenzoni, Simon Hodge, Anina Knauer, Marion Laurent, Vicente Martínez‐López, Risto Raimets, Janine M. Schwarz, Deepa Senapathi, Giorgia Serra, Giovanni Tamburini, Dimitry Wintermantel, Mark J. F. Brown, Matthias Albrecht, Cecilia Costa, Pilar De la Rúa, Alexandra‐Maria Klein, Marika Mänd, Simon G. Potts, Maj Rundlöf, Oliver Schweiger, Jane C. Stout, Denis Michez   +34 more
wiley   +1 more source

Development and validation of stability indicating RP-HPLC method for the simultaneous estimation of dapagliflozin and eplerenone in bulk and synthetic mixture. [PDF]

BMC Chem
Tandel P, Mehta H.
europepmc   +1 more source

A new branch of mammalian vitamin B6 metabolism: AKR1C‐mediated conversion of pyridoxal to pyridoxine and 4‐pyridoxolactone

The FEBS Journal, EarlyView.
Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito, Yasuyuki Kitaura, Kyoka Iino, Kazuya Toriumi, Hyunah Noh, Naoya Ogawa, Makoto Arai, Hisashi Hemmi, Tomokazu Ito   +8 more
wiley   +1 more source

Validated comprehensive RP HPLC approach for separation and quantification of solifenacin and mirabegron in the presence of their degradation products. [PDF]

Sci Rep
Kamel EB, Badrawy M, Nour IM.
europepmc   +1 more source