Results 41 to 50 of about 111,748 (238)

A validated RP-HPLC method for simultaneous determination of propranolol and valsartan in bulk drug and gel formulation

open access: yesJournal of Pharmacy and Bioallied Sciences, 2013
Objective: A simple, precise, and stability indicating high performance liquid chromatography (HPLC) method was developed and validated for the simultaneous determination of propranolol hydrochloride and valsartan in pharmaceutical dosage form. Materials
Syed Sarim Imam   +4 more
doaj   +1 more source

Developing an Analytical Method for Separating and Quantifying RNA Generated in In Vitro Transcription Reactions [PDF]

open access: yes, 2015
The generation of run-off transcripts from in vitro transcription reactions is a useful technique in the study of transcription regulation. There are currently limited ways in which these run-off transcripts can be analyzed, and few that are truly ...
Wienkers, Henry
core   +1 more source

Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant\ue2\u80\u93anticoagulant equilibrium toward thrombosis [PDF]

open access: yes, 2017
Blood coagulation is a finely regulated physiological process culminating with the factor Xa (FXa)-mediated conversion of the prothrombin (ProT) zymogen to active -thrombin (T).
Acquasaliente, Laura   +5 more
core   +1 more source

Quality by design based ecofriendly HPLC analytical method for simultaneous quantification of erastin and lenalidomide in mesoporous silica nanoparticles

open access: yesScientific Reports
The aims of this work to optimize and validate a RP-HPLC method to quantify erastin (ERT) and lenalidomide (LND) in mesoporous silica nanoparticles (MSNs). The Design of Experiments (DoE) strategy optimized the RP-HPLC method.
Ashutosh Gupta   +3 more
doaj   +1 more source

Reverse Phase High-performance Liquid Chromatography: A Comprehensive Review of Principles, Instrumentation, Analytical Procedures, and Pharmaceutical Applications

open access: yesJournal of Preventive, Diagnostic and Treatment Strategies in Medicine
A popular analytical method in the domains of material sciences, pharmacology, biology, the environment, food, cosmetics, and forensics is reverse phase high-performance liquid chromatography (RP-HPLC). Both polar and nonpolar molecules may be separated,
Suman Basak, Piyali Das
doaj   +1 more source

Method operable design region for robust RP-HPLC analysis of pioglitazone hydrochloride and teneligliptin hydrobromide hydrate: incorporating hybrid principles of white analytical chemistry and design of experiments

open access: yesFuture Journal of Pharmaceutical Sciences, 2023
Background A combination of pioglitazone hydrochloride with teneligliptin hydrobromide hydrate is used to treat type-2 diabetes. Several chromatographic techniques have been described in the literature for determination of each of these medications ...
Pintu Prajapati   +3 more
doaj   +1 more source

Separation of Nucleic Acids by Ion Pair Reversed Phase High Performance Liquid Chromatography (IP RP HPLC) [PDF]

open access: yes, 2019
Ion-pair reversed-phase high performance liquid chromatography (IP RP HPLC) is shown to be an effective method to reliably analyze DNA. IP RP HPLC is a much faster and safer alternative to conventional methods of DNA separation and quantification.
Bestwick, Megan, McLeod, Zachary
core   +1 more source

A Non-Covalent Antibody Complex for the Delivery of anti-cancer drugs [PDF]

open access: yes, 2019
Antibody drug conjugates (ADCs), which are obtained by coupling a potent cytotoxic agent to a monoclonal antibody (mAb), are traditionally bound in a random way to lysine or cysteine residues, with the final product's heterogeneity having an important ...
Grigoletto, Antonella   +5 more
core   +1 more source

PENENTUAN WAKTU MATI MEMANFAATKAN DERET HOMOLOG ALKILPARABEN PADA RP-HPLC DALAM SISTEM PELARUT METANOL/AIR

open access: yesJurnal Natural, 2016
Penelitian ini dalam rangka pengembangan dan aplikasi metode penentuan waktu mati (t0) pada Kromatografi Cair dari yang telah pernah dan berhasil diterapkan di GC.
Mahmudi .   +3 more
doaj   +2 more sources

DEVELOPMENT OF METHODS FOR DETERMINATION OF SPECIFIC IMPURITIES IN THE GLUTATIONION RESTORED SUBSTANCE

open access: yesФармация и фармакология (Пятигорск), 2019
Glutathione (γ-L-glutamyl-L-cysteinylglycine) is the most important low molecular weight intracellular thiol tripeptide consisting of three amino acids – glycine, cysteine and glutamic acid.
K. A. Alexeeva   +3 more
doaj   +1 more source

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