Results 41 to 50 of about 67,204 (291)

A Photochemical Macrocyclization Route to Asymmetric Strained [3.2] Paracyclophanes

Chemistry – A European Journal, Volume 28, Issue 69, December 9, 2022., 2022
A novel synthetic route to strained cyclophanes is reported, which involves the unexpected photochemical fusion of a carboxylic ester and a non‐activated methyl group. Functional experiments suggest that the previously overlooked C−C bond forming reaction involves an excited triplet state and intramolecular hydrogen abstraction. Using a flow reactor, a
Veit G. Haensch, Helmar Görls, Christian Hertweck   +2 more
wiley   +1 more source

Ribozyme‐Catalyzed Site‐Specific Labeling of RNA Using O6‐alkylguanine SNAP‐Tag Substrates

Angewandte Chemie, EarlyView.
SNAPR is a ribozyme that repurposes O6‐benzylguanine SNAP‐tag substrates for site‐specific labeling of RNA with bioorthogonal alkyne and azide functional groups, fluorophores or photocrosslinkers. The N1A‐alkylated RNA products were converted to N6A‐modified RNA by Dimroth rearrangement.
Manisha B. Walunj, Carolin P. M. Scheitl, Tina Jungnickel, Claudia Höbartner   +3 more
wiley   +2 more sources

PENENTUAN WAKTU MATI MEMANFAATKAN DERET HOMOLOG ALKILPARABEN PADA RP-HPLC DALAM SISTEM PELARUT METANOL/AIR

Jurnal Natural, 2016
Penelitian ini dalam rangka pengembangan dan aplikasi metode penentuan waktu mati (t0) pada Kromatografi Cair dari yang telah pernah dan berhasil diterapkan di GC.
Mahmudi ., Saiful ., Khairan ., Rinaldi Idroes   +3 more
doaj   +2 more sources

Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response

Advanced Healthcare Materials, EarlyView.
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim, Jin Woong Lee, Piper A. Rawding, Mari Iida, Carter Kim, Kourtney L. Kostecki, Michael J. Poellmann, Bridget Crossman, Ashley S. Liu, YoungSoo Kim, Deric L. Wheeler, Seungpyo Hong   +11 more
wiley   +1 more source

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

Angewandte Chemie, EarlyView.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kita   +5 more
wiley   +2 more sources

Zero‐Power, Optical Toxic Gas and Vapor Sensors Utilizing Printed Nematic Liquid Crystal Patterns on Selectively Reactive Substrates

Advanced Sensor Research, EarlyView.
Fast response, zero‐power, text or image sensors utilizing light transmission or reflection, and no unfavorable color change judgments, are fabricated using printed nematic liquid crystals patterned on reactive alignment layers, permit ppt‐ to ppb‐level sensitivity, and were field‐tested with active firefighters.
Ryan A. Williams, Grace A. R. Rohaley, Ashwathanarayana Gowda, Gisele Pegorin, Andrea Oprandi, Denis Motovilov, Anthony Schneider, Elda Hegmann, Marianne E. Prévôt, Torsten Hegmann   +9 more
wiley   +1 more source

RP-HPLC analysis of methanol extract of Viscum articulatum

Journal of Ayurveda and Integrative Medicine, 2020
Viscum articulatum Burm. (Family: Loranthaceae) is commonly known as mistletoe. In ayurveda, the plant parts are used in "Kapha", "Vata", diseases of the blood, ulcer, and epilepsy. The plant parts are also used in urinary tract infection and wound infection.
Mrinmoy Nag, Amit Kar, Joydeb Chanda, Pulok K. Mukherjee   +3 more
openaire   +2 more sources

Dual Charge Transfer Mechanisms in Intimately Bonded S‐scheme Heterojunction Photocatalyst with Expeditious Activity toward Environmental Remediation

Advanced Sustainable Systems, EarlyView.
A novel MBOdCN S‐scheme heterojunction photocatalyst is fabricated using pristine Mg‐Bi2O3 and grayish g‐C3N4, where dynamic dual charge migration paths occur to accelerate exciton dissociation. This composite catalyst realizes high degradation efficiency of up to 99.56% of oxytetracycline (OTC) removal under optimized conditions. The material exhibits
Potlako J. Mafa, Mope E. Malefane, Francis Opoku, Adewale O. Oladipo, Gcina Mamba, Tunde L. Yusuf, Jemal Fito Nure, Sogolo L. Lebelo, Dan Liu, Jianzhou Gui, Bhekie B. Mamba, Alex T. Kuvarega   +11 more
wiley   +1 more source

Determination of Ketoprofen in Human Plasma by RP-HPLC [PDF]

American Journal of Analytical Chemistry, 2013
For in vivo pharmacokinetic studies, it is pre-requisite to quantify drug concentrations in plasma. In the present study a RP-HPLC procedure was developed and validated for the assessment of ketoprofen in human plasma. For this purpose mobile phase consisting of methaol:water (70:30) adjusted to pH 3.3 with phosphoric acid was used, and ...
Asia Naz, Rabia Ismail Yousuf, Farya Zafar, Muhammad Shoaib, Huma Ali   +4 more
openaire   +2 more sources

Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance

Advanced Therapeutics, EarlyView.
Antimicrobial resistance necessitates the development of new antibiotics with “resistance‐breaking” properties. In this study, conjugation of polycationic peptides is proven to represent a versatile strategy for the fast and affordable reactivation of daptomycin.
Sari Rasheed, Florian Umstätter, Eric Mühlberg, Barbro Beijer, Tobias Hertlein, Karel D. Klika, Christian Kleist, Julia Werner, Cornelius Domhan, Mara Bingel, Anna Müller, Marvin Rausch, Stefan Zimmermann, Knut Ohlsen, Uwe Haberkorn, Marcus Koch, Markus Bischoff, Tanja Schneider, Rolf Müller, Jennifer Herrmann, Walter Mier, Philipp Uhl   +21 more
wiley   +1 more source