Results 11 to 20 of about 89 (73)
Cdk7 mediates RPB1-driven mRNA synthesis in Toxoplasma gondii [PDF]
Scientific Reports, 2016 AbstractCyclin-dependent kinase 7 in conjunction with CyclinH and Mat1 activates cell cycle CDKs and is a part of the general transcription factor TFIIH. Role of Cdk7 is well characterized in model eukaryotes however its relevance in protozoan parasites has not been investigated.
Abhijit S. Deshmukh +2 more
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Rpb1 Sumoylation in Response to UV Radiation or Transcriptional Impairment in Yeast
PLoS ONE, 2009 Covalent modifications of proteins by ubiquitin and the Small Ubiquitin-like MOdifier (SUMO) have been revealed to be involved in a plethora of cellular processes, including transcription, DNA repair and DNA damage responses. It has been well known that in response to DNA damage that blocks transcription elongation, Rpb1, the largest subunit of RNA ...
Xuefeng Chen +4 more
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Selective kinase inhibition shows that Bur1 (Cdk9) phosphorylates the Rpb1 linker in vivo [PDF]
Molecular and Cellular Biology, 2018 Cyclin-dependent kinases play multiple roles in RNA polymerase II transcription. Cdk7/Kin28, Cdk9/Bur1, and Cdk12/Ctk1 phosphorylate the polymerase and other factors to drive the dynamic exchange of initiation and elongation complex components over the transcription cycle.
Chun, Yujin +6 more
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Phosphorylation of the Yeast Rpb1 C-terminal Domain at Serines 2, 5, and 7 [PDF]
Journal of Biological Chemistry, 2009 The C-terminal domain (CTD) of Rpb1, the largest subunit of RNA polymerase II, acts as a binding platform for various mRNA processing and histone-modifying enzymes that act co-transcriptionally. These factors are targeted to specific phosphorylation states of the CTD that predominate at different stages of transcription.
Minkyu, Kim +3 more
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The interaction between the Spt6-tSH2 domain and Rpb1 affects multiple functions of RNA Polymerase II [PDF]
Nucleic Acids Research, 2021 Abstract The conserved transcription elongation factor Spt6 makes several contacts with the RNA Polymerase II (RNAPII) complex, including a high-affinity interaction between the Spt6 tandem SH2 domain (Spt6-tSH2) and phosphorylated residues of the Rpb1 subunit in the linker between the catalytic core and the C-terminal domain (CTD ...
Zaily Connell +4 more
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Mutations in the Saccharomyces cerevisiae RPB1 Gene Conferring Hypersensitivity to 6-Azauracil [PDF]
Genetics, 2006 Abstract RNA polymerase II (RNAPII) in eukaryotic cells drives transcription of most messenger RNAs. RNAPII core enzyme is composed of 12 polypeptides where Rpb1 is the largest subunit. To further understand the mechanisms of RNAPII transcription, we isolated and characterized novel point mutants of RPB1 that are sensitive to the ...
Francisco, Malagon +5 more
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Mammalian Elongin A complex mediates DNA‐damage‐induced ubiquitylation and degradation of Rpb1 [PDF]
The EMBO Journal, 2008 The Elongin complex stimulates the rate of transcription elongation by RNA polymerase II (pol II) by suppressing transient pausing of the pol II at many sites along the DNA. Elongin is composed of a transcriptionally active A subunit and two small regulatory B and C subunits, which can form an isolable Elongin ...
Takashi, Yasukawa +5 more
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The Set2-RPB1 Interaction Domain of Human RECQ5 Is Important for Transcription-Associated Genome Stability [PDF]
Molecular and Cellular Biology, 2011 The conserved RECQ5 DNA helicase is a tumor suppressor in mammalian cells. Defects in RECQ5 lead to the accumulation of spontaneous DNA double-stranded breaks (DSBs) during replication, despite the fact that these cells are proficient in DSB repair by homologous recombination (HR). The reason for this is unknown.
Min, Li, Xiaohua, Xu, Yilun, Liu
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Frequency and Mechanism of Expansion of the C‐terminal Domain of Yeast RPB1
The FASEB Journal, 2015 The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II, RPB1, is made up of tandem heptapeptide repeats whose residues are heavily post-translationally modified, helping to ...
Summer Morrill, Stephen Fuchs
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Using RPB1 sequences to improve phylogenetic inference among mushrooms (Inocybe, Agaricales) [PDF]
American Journal of Botany, 2002 An investigation of mushroom phylogeny using the largest subunit of RNA polymerase II gene sequences (RPB1) was conducted in comparison with nuclear ribosomal large subunit RNA gene sequences (nLSU) for the same set of taxa in the genus Inocybe (Agaricales, Basidiomycota).
P Brandon, Matheny +3 more
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