Results 51 to 60 of about 2,193 (173)

Structural and functional specialization of Bordetella pertussis DsbA for pertussis toxin folding

open access: yesProtein Science, Volume 35, Issue 1, January 2026.
Abstract Disulphide bonds (Dsbs) are essential for the folding, stability, and function of many secreted and membrane‐associated proteins in bacteria. In Gram‐negative species, these bonds are introduced by the Dsb enzyme family, with DsbA acting as the primary thiol oxidase.
Stephanie Penning   +9 more
wiley   +1 more source

Molecular basis of domain‐specific angiotensin I‐converting enzyme inhibition by the antihypertensive drugs enalaprilat, ramiprilat, trandolaprilat, quinaprilat and perindoprilat

open access: yesThe FEBS Journal, Volume 293, Issue 2, Page 475-491, January 2026.
Inhibition of angiotensin I‐converting enzyme is an effective strategy for the treatment of hypertension. However, the clinically available ACE inhibitors cause side effects due to nonselective inhibition of the two catalytic domains of ACE (nACE and cACE).
Kyle S. Gregory   +3 more
wiley   +1 more source

Structural Insights Into the Nuclear Import of Marek’s Disease Virus Large Tegument Protein

open access: yesAdvances in Virology, Volume 2026, Issue 1, 2026.
Marek’s disease (MD) is a highly contagious neoplastic disorder of poultry caused by MD virus (MDV; gallid alphaherpesvirus 2 [GaAHV2]). Infection results in profound immunosuppression, neurological dysfunction, and the development of malignant T‐cell lymphomas.
Babu Kanti Nath   +7 more
wiley   +1 more source

Numerical Analysis of Rectangular Isotropic and Orthotropic Thin Plates Based on the Radial Point Interpolation Method (RPIM) [PDF]

open access: yesInternational Journal of Advanced Design and Manufacturing Technology, 2010
In the recent paper, one of the numerical methods without element, for static analysis of thin plates displacement based on classical plates theory (CPT), has been presented.
MohamadMehdi Najafzadeh   +3 more
doaj  

Dynamic Anchoring of Peptides to the Extracellular Matrix Enabled by Boronic Acid

open access: yesChemBioChem, Volume 26, Issue 24, December 11, 2025.
Peptides are developed for reversible binding to sugar‐rich structures (glycans) in cell‐derived extracellular matrix models using boronic acid chemistry. By attaching a carboxy‐phenyl‐boronic acid group to the N‐terminus of peptides, a modified myostatin inhibitor is synthesized that retaines biological activity comparable to standard inhibitors. This
Martin Mergenthaler   +5 more
wiley   +1 more source

Numerical Simulation of Skew Extension Rolling Process by Radial Points Interpolation Method(RPIM)

open access: yes工程科学与技术, 2013
:By applying flow rule of micro compression rigid plastic material, a three dimensional calculation model based on radial basis points interpolation RPIM of skew extension rolling process was established.The radial basis function has Delta function ...
孙杰   +4 more
doaj  

A unified three-dimensional meshless analysis of vibration and thermal buckling of variable-thickness cylindrical shells

open access: yesResults in Engineering
This paper presents a comprehensive analysis of free vibrations and thermal buckling of cylindrical shells with variable thickness, formulated based on three-dimensional elasticity theory and the variational principle. The governing equations are derived
Reza Pilafkan, Vahid Arab Maleki
doaj   +1 more source

The Biomechanical Analysis of Tibial Implants Using Meshless Methods: Stress and Bone Tissue Remodeling Analysis

open access: yesDesigns
Total knee arthroplasty (TKA) stands out as one of the most widely employed surgical procedures, establishing itself as the preferred method for addressing advanced osteoarthritis of the knee.
Ana Pais   +2 more
doaj   +1 more source

Dynamic Analysis with Three Beam Theories for a Rotating FGM Micro-Beam Based on Meshless Methods

open access: yesApplied Sciences
This paper investigates the dynamic characteristics of rotating functionally graded material (FGM) micro-beams based on Euler–Bernoulli beam theory, Euler–Bernoulli beam theory incorporating shear deformation, and Timoshenko theory. The deformation field
Chaofan Du   +6 more
doaj   +1 more source

A nodal integration technique for meshfree radial point interpolation method (NI-RPIM)

open access: yesInternational Journal of Solids and Structures, 2007
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Liu, G.R.   +5 more
openaire   +2 more sources

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