Results 41 to 50 of about 2,193 (173)

Oxidized mtDNA Contributes to Pulmonary Inflammation and Fibrosis in Bleomycin‐Induced Lung Injury

MedComm, Volume 7, Issue 4, April 2026.
In this study, we demonstrate that bleomycin induces the release of reactive oxygen species (ROS), resulting in oxidative damage to mitochondrial DNA (mtDNA), which subsequently triggers neutrophil infiltration and M2 macrophage polarization in the lungs of mice. These events ultimately contribute to the development of pulmonary fibrosis. Additionally,
Ye Mao, Xinyu Tian, Jiayuan Ai, Xiaoting Zhou, Yanghong Ni, Dandan Wan, Min Luo, Xiawei Wei   +7 more
wiley   +1 more source

Numerical Solution of Natural Convection Problems Using Radial Point Interpolation Meshless (RPIM) Method Combined with Artificial-Compressibility Model

Mathematical and Computational Applications
A numerical method is used to solve the thermal analysis of natural convection in enclosures. This paper proposes the use of an implicit artificial-compressibility model in conjunction with the Radial Point Interpolation Meshless (RPIM) method to mimic ...
Pranowo, Albertus Joko Santoso, Agung Tri Wijayanta   +2 more
doaj   +1 more source

Neutron Crystallography Study of Host–Pathogen Recognition Enhanced by Hydrogen/Deuterium Exchange on Carbohydrates

ChemistryEurope, Volume 4, Issue 3, March 2026.
Neutron macromolecular crystallography enabled by deuteration of biomolecules reveals how the opportunistic pathogen Pseudomonas aeruginosa utilizes calcium‐dependent lectin for binding to human sugars. Neutron diffraction on the complex highlights hydrogen bond network, protonation of amino acids and role of calcium ion.
Theodore Arnaud, Chloé Tatol, Juliette M. Devos, Lukas Gajdos, Sébastien Vidal, Marek Korsak, Annabelle Varrot, Michaela Wimmerova, Sophie Feuillastre, Matthew P. Blakeley, Anne Imberty   +10 more
wiley   +1 more source

Experience with the Jungfrau‐1M detector at Diamond Light Source

Journal of Synchrotron Radiation, Volume 33, Issue 2, Page 331-343, March 2026.
A Jungfrau‐1M integrating detector was characterized at Diamond Light Source and found to be effective for recording macromolecular crystallography diffraction patterns. Parameters for operation and data collection were explored and characterized. The Diamond facility will be upgraded and integrating detectors, such as Jungfrau, will be used more ...
John Matheson, Danny Axford, Anna Bergamaschi, Maria Carulla, Nicholas Devenish, Noemi Frisina, Viktoria Hinger, Vadym Kedych, Christopher Lane, Aldo Mozzanica, Eva Gimenez-Navarro, James O'Hea, Dominic Oram, Robin L. Owen, David Perl, Adam Prescott, Bernd Schmitt, Shane Scully, Adam Taylor, Gary Yendell, Graeme Winter   +20 more
wiley   +1 more source

An efficient RPIM for simulating wave motions in saturated porous media

International Journal of Solids and Structures, 2008
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Chen, S. L., Li, Y. X.
openaire   +1 more source

Mesh-free kinematic shakedown analysis of cohesive soils

International Journal of Geo-Engineering
A novel mesh-free solution is proposed for kinematic shakedown analysis of cohesive soils under repeating loads. For this purpose, the continuous velocity field in the mathematical expression of Koiter’s theorem is discretized by the Radial Point ...
Z. Nosrati, S. M. Binesh
doaj   +1 more source

Solución del problema de Kirsch mediante elementos libres de malla, utilizando funciones de interpolación de base radial

Ingeniería y Ciencia, 2017
El problema de Kirsch publicado en 1898, es utilizado como base para corroborar la precisión relativa de los métodos numéricos desarrollados en la mecánica de sólidos.
Fabio H Realpe, Yasser H Ochoa, Francisco Franco, Pedro J Díaz   +3 more
doaj   +1 more source

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science, Volume 13, Issue 11, 23 February 2026.
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao, Siyuan Chai, Mingyang Li, Xiaoming Chen, Jiating Hu, Bingyi Lin, Liming Wu, Wen Yi, Qiang Zhu   +8 more
wiley   +1 more source

The Crystal Structure of Human Transport and Golgi Organization 2 Homolog (TANGO2) Protein Reveals an αββα‐Fold Arrangement

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 2, Page 515-528, February 2026.
ABSTRACT Transport and Golgi Organization 2 Homolog (TANGO2) protein deficiency disorder (TDD) is a rare autosomal recessive disorder characterized by multi‐systemic abnormalities and significant phenotypic variability including neurodevelopmental delay, seizures, intermittent ataxia, hypothyroidism, rhabdomyolysis, life‐threatening metabolic ...
Anne Cooper, Alyssa Powers, Kevin P. Battaile, Al‐Walid Mohsen, David K. Johnson, Scott Lovell, Lina Ghaloul‐Gonzalez   +6 more
wiley   +1 more source