Results 211 to 220 of about 193,591 (315)

Modelling the Black Carbon Variability and Dynamics in Almaty, Kazakhstan, During Winter and Summer Seasons

open access: yesMeteorological Applications, Volume 33, Issue 3, May/June 2026.
The study investigates the seasonal transport of black carbon (BC) from Almaty, Kazakhstan, to adjacent mountain areas. The radiative effects associated with BC are evaluated at the surface, within the atmosphere, and at the top of the atmosphere. ABSTRACT Large cities with poor air quality can affect surrounding areas through pollutant transport and ...
Madina Tursumbayeva   +5 more
wiley   +1 more source

Pharmacometric Analysis of Cafedrine/Theodrenaline Versus Ephedrine on Maternal Hemodynamics and Neonatal Acidosis During Cesarean Section. [PDF]

open access: yesPharmaceutics
Dings C   +9 more
europepmc   +1 more source

Evaluation of Current and Novel Dosing Strategies for Anti‐Thymocyte Globulin in Adult Allogeneic Hematopoietic Stem Cell Transplantation

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Anti‐thymocyte globulin (ATG) is a polyclonal antibody used to prevent graft‐versus‐host disease in allogeneic hematopoietic stem cell transplantation. While recent studies have worked towards understanding the pharmacokinetic–pharmacodynamic relationship via population pharmacokinetic modeling, dosing remains weight‐based and largely ...
Elias Biris   +3 more
wiley   +1 more source

Population Pharmacokinetics and Pharmacokinetics‐Pharmacodynamics Analyses of Elafibranor to Support Dose Selection in Primary Biliary Cholangitis

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Elafibranor 80 mg/day is approved for second‐line primary biliary cholangitis (PBC) treatment. We present pharmacokinetic (PK) analyses of elafibranor and its metabolite, GFT1007, and pharmacokinetic‐pharmacodynamic (PKPD) analyses describing the relationship between their exposure and responses in alkaline phosphatase (ALP) and total ...
Qing Xi Ooi   +5 more
wiley   +1 more source

Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial. [PDF]

open access: yesAdv Sci (Weinh)
Samarasekera S   +12 more
europepmc   +1 more source

Integration of Time‐Varying Pharmacometric Modeling With Cox Regression for Time‐to‐Event Analysis in NONMEM

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Although time‐varying Cox regression modeling approaches have been developed, exposure–response analyses for time‐to‐event (TTE) endpoints often rely on static exposure covariates and may overlook the real‐world dosing variability and drug concentration fluctuations over time. To better characterize pharmacokinetic (PK) or pharmacodynamic (PD)
Chih‐Wei Lin   +3 more
wiley   +1 more source

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