Results 61 to 70 of about 152,172 (364)

RSV awareness, risk perception, causes, and terms: Perspectives of pregnant and lactating women in Kenya to inform demand generation efforts for maternal RSV vaccines

Human Vaccines & Immunotherapeutics, 2023
Respiratory syncytial virus (RSV) causes a substantial proportion of acute lower respiratory tract infections (LRTI) among infants. In low- and middle-income countries, RSV may be responsible for approximately 40% of all hospital admissions of infants ...
Rupali J. Limaye, Berhaun Fesshaye, Prachi Singh, Ruth A. Karron   +3 more
doaj   +1 more source

Respiratory syncytial virus: Clinical and epidemiological pattern in pediatric patients admitted to a children’s hospital between 2000 and 2013 [PDF]

, 2014
INTRODUCTION: Respiratory syncytial virus (RSV) is the major causative organism associated with acute lower respiratory tract infections in children.The objective of this study was to describe the clinical and epidemiological pattern of RSV and identify ...
Bakir, Julia, Castellano, Verónica, Gentile, Ángela, Grobaporto, Marcela, Juárez, María del Valle, Lucion, María Florencia, Mistchenko, Alicia Susana, Romanin, Viviana Sandra, Viegas, Mariana   +8 more
core   +1 more source

Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection

npj Vaccines, 2020
The RSV Fusion (F) protein is a target for neutralizing antibody responses and is a focus for vaccine discovery; however, the process of RSV entry requires F to adopt a metastable prefusion form and transition to a more stable postfusion form, which ...
Amy S. Espeseth, P. Cejas, Michael P. Citron, Dai Wang, D. Distefano, Cheryl Callahan, Gregory O ’ Donnell, Jennifer D Galli, Ryan Swoyer, Sinoeun Touch, Zhiyun Wen, J. Antonello, Lan Zhang, Jessica Flynn, K. Cox, D. Freed, K. Vora, Kapil Bahl, Andrew H. Latham, Jeffrey S. Smith, Marian E. Gindy, G. Ciaramella, D. Hazuda, C. Shaw, A. Bett   +24 more
semanticscholar   +1 more source

RSV A2-Based Prefusion F Vaccine Candidates Induce RSV A and RSV B Cross Binding and Neutralizing Antibodies and Provide Protection against RSV A and RSV B Challenge in Preclinical Models

Vaccines, 2023
RSV is divided into two antigenic subtypes, RSV A and RSV B, which is largely based on the variation in the G protein, while the fusion protein F is more conserved and a target for antibody-mediated neutralization. Here we evaluate the breadth of the protective immune responses across RSV A and RSV B subtypes, induced by vaccines based on the RSV A ...
Freek Cox, Eirikur Saeland, Anne Thoma, Ward van den Hoogen, Lisanne Tettero, Joke Drijver, Cornelis Vaneman, Yolinda van Polanen, Tina Ritschel, Arangassery Rosemary Bastian, Benoit Callendret, Roland Zahn, Leslie van der Fits   +12 more
openaire   +3 more sources

De novo protein design enables the precise induction of RSV-neutralizing antibodies

Science, 2020
TopoBuilding precision vaccines To induce strong and targeted neutralizing antibody (nAb) responses against vaccine targets, one strategy has been to use computationally designed immunogens. However, the structural complexity of many known neutralization
F. Sesterhenn, Che Yang, J. Bonet, J. T. Cramer, X. Wen, Yimeng Wang, Chi-I Chiang, L. Abriata, I. Kucharska, G. Castoro, Sabrina S. Vollers, M. Galloux, E. Dheilly, S. Rosset, P. Corthésy, S. Georgeon, M. Villard, Charles-Adrien Richard, D. Descamps, T. Delgado, E. Oricchio, M. Rameix-Welti, V. Mas, S. Ervin, J. Éléouët, S. Riffault, J. Bates, J. Julien, Yuxing Li, T. Jardetzky, T. Krey, B. Correia   +31 more
semanticscholar   +1 more source

Roadblocks to translational challenges on viral pathogenesis. [PDF]

, 2013
Distinct roadblocks prevent translating basic findings in viral pathogenesis into therapies and implementing potential solutions in the clinic. An ongoing partnership between the Volkswagen Foundation and Nature Medicine resulted in an interactive ...
Deeks, Steven, Drosten, Christian, Picker, Louis, Subbarao, Kanta, Suzich, Joann   +4 more
core   +1 more source

Comparison of the Xpert Flu/RSV XC and Xpress Flu/RSV Assays [PDF]

Journal of Clinical Microbiology, 2018
Molecular diagnostics for influenza and respiratory syncytial virus (RSV) have become commonplace, and various tests and systems have been cleared by the FDA for use in the United States. We performed a retrospective study to compare the Cepheid Xpress Flu/RSV assay with the Xpert Flu/RSV XC assay, using laboratory-developed tests (LDTs) as the ...
Elena B. Popowitch, Melissa B. Miller
openaire   +2 more sources

RSV genomic diversity and the development of a globally effective RSV intervention

Vaccine, 2021
Respiratory syncytial virus (RSV) is the most common cause of serious lower respiratory tract illness in infants and children and causes significant disease in the elderly and immunocompromised. Recently there has been an acceleration in the development of candidate RSV vaccines, monoclonal antibodies and therapeutics.
Sonnie Kim, Thomas C. Williams, Cecile Viboud, Harry Campbell, Jiani Chen, David J. Spiro   +5 more
openaire   +3 more sources

The respiratory syncytial virus nucleoprotein–RNA complex forms a left-handed helical nucleocapsid [PDF]

, 2013
Respiratory Syncytial Virus (RSV) is an important human pathogen. Its nucleocapsid (NC), which comprises the negative sense RNA viral genome coated by the viral nucleoprotein N, is a critical assembly that serves as template for both mRNA synthesis and ...
Bhella, Colin Loney, David Bhella, Edward Conner, Egelman, Fix, Félix A. Rey, Jean-François Eléouët, Marie Galloux, Saskia E. Bakker, Stéphane Duquerroy   +10 more
core   +2 more sources

Efficacy and Safety of Respiratory Syncytial Virus (RSV) Prefusion F Protein Vaccine (RSVPreF3 OA) in Older Adults Over 2 RSV Seasons

Clinical Infectious Diseases
Background The adjuvanted RSV prefusion F protein–based vaccine (RSVPreF3 OA) was efficacious against RSV-related lower respiratory tract disease (RSV-LRTD) in ≥60-years-olds over 1 RSV season.
Michael G. Ison, Alberto Papi, Eugene Athan, Robert G. Feldman, Joanne M Langley, Dong-Gun Lee, I. Leroux-Roels, F. Martinón-Torres, Tino F. Schwarz, Richard N van Zyl-Smit, Céline Verheust, N. Dezutter, Olivier Gruselle, L. Fissette, M. David, L. Kostanyan, Veronica Hulstrøm, Aurélie Olivier, M. Van der Wielen, Dominique Descamps   +19 more
semanticscholar   +1 more source